[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.145.218.90. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
October 1982

Talc Retinopathy in Primates: A Model of Ischemic RetinopathyIII. An Electron Microscopic Study

Author Affiliations

From the University of Illinois Hospital Eye and Ear Infirmary, Chicago.

Arch Ophthalmol. 1982;100(10):1649-1657. doi:10.1001/archopht.1982.01030040627015
Abstract

• Electron microscopic study of experimental talc retinopathy provides an opportunity to study the basic cytologic response of retinal and choroidal vessels to small, relatively inert emboli. Occlusion of the retinal and choroidal capillaries resulted primarily from the cellular reaction to, rather than directly from, the emboli. Mitotic figures in pericytes were observed. Even though we failed to produce retinal neovascularization (as is sometimes seen in human talc retinopathy) in this experimental model, our observations suggest that proliferation of pericytes may be an initial step in the process of retinal neovascularization.

References
1.
Atlee WE Jr:  Talc and cornstarch emboli in eyes of drug abusers . JAMA 1972;219:49-51.Article
2.
Friberg TR, Gragoudas ES, Regan CDJ:  Talc emboli and macular ischemia in intravenous drug abuse . Arch Ophthalmol 1979;97:1089-1091.Article
3.
Lee J, Sapira JD:  Retinal and cerebral microembolization of talc in a drug abuser . Am J Med Sci 1973;265:75-77.Article
4.
Schatz H, Drake M:  Self-injected retinal emboli . Ophthalmology 1979;86:468-485.Article
5.
Kresca LJ, Goldberg MF, Jampol LM:  Talc emboli and retinal neovascularization in a drug abuser . Am J Ophthalmol 1979;87:334-339.
6.
Brucker AJ:  Disk and peripheral retinal neovascularization secondary to talc and cornstarch emboli . Am J Ophthalmol 1979;88:864-867.
7.
Jampol LM, Setogawa T, Tso MOM, et al:  Talc retinopathy in primates: A model of ischemic retinopathy: I. Clinical studies . Arch Ophthalmol 1981;99:1273-1280.Article
8.
Cook CAG:  Role of fat emboli in diabetic retinopathy . Br J Ophthalmol 1957;41:741-745.Article
9.
Hirose K, Baba K:  A study of Takayasu-Ohnishi's (pulseless) disease . Am J Ophthalmol 1963;55:554-568.
10.
Hollenhorst RW, Lensink ER, Whisnant JP:  Experimental embolization of the retinal arterioles . Trans Am Ophthalmol Soc (AM) 1964;60:316-334.
11.
Gay AJ, Goldor H, Smith M:  Chorioretinal vascular occlusions with latex spheres . Invest Ophthalmol Vis Sci 1964;3:647-656.
12.
Ashton N, Henkind P:  Experimental occlusion of retinal arterioles (using graded glass ballotini) . Br J Ophthalmol 1965;49:225-234.Article
13.
Dollery CT, Henkind P, Paterson JW, et al:  Focal retinal ischemia . Br J Ophthalmol 1966;50:285-324.Article
14.
Goldor H, Gay AJ:  Chorioretinal vascular occlusion with latex microspheres (a long-term study) . Invest Ophthalmol Vis Sci 1967;6:51-58.
15.
Kloti R:  Experimental occlusion of retinal and ciliary vessels in owl monkeys . Exp Eye Res 1967;6:393-399.Article
16.
Stern WH, Ernest JT:  Microsphere occlusion of the choriocapillaris in rhesus monkeys . Am J Ophthalmol 1974;78:438-448.
17.
Pare JAP, Fraser RG, Hogg JC, et al:  Pulmonary mainline granulomatosis: Talcosis of intravenous methadone abuse . Medicine 1979;58:229-239.
18.
Tso MOM, Bettman JW:  Occlusion of choriocapillaris in primary nonfamilial amyloidosis . Arch Ophthalmol 1971;86:281-286.Article
19.
Fine BS, Kwapien RP:  Pigment epithelial windows and drusen: An animal model . Invest Ophthalmol Vis Sci 1978;17:1059-1068.
20.
Tso MOM, Shih CY:  Experimental macular edema after lens extraction . Invest Ophthalmol Vis Sci 1977;16:381-392.
21.
Grimes PA, Laties AM:  Early morphologic alteration of the pigment epithelium in streptozotocin-induced diabetes: Increased surface area of the basal cell membrane . Invest Ophthalmol Vis Sci 1979;18( (suppl) ):17.
22.
Engerman RL, Pfaffenbach D, Davis MD:  Cell turn-over of capillaries . Lab Invest 1967;17:738-743.
23.
Deem CW, Futterman S, Kalina RE:  Induction of endothelial cell proliferation in rat retinal venules by chemical and indirect physical trauma . Invest Ophthalmol Vis Sci 1974;13:580-585.
24.
Reinecke RD, Kuwabara T, Cogan DG, et al:  Retinal vascular patterns: V. Experimental ischemia of the cat eye . Arch Ophthalmol 1962;67:470-475.Article
25.
Wallow IHL, Engerman RL:  Permeability and patency of retinal blood vessels in experimental diabetes . Invest Ophthalmol Vis Sci 1977;16:447-461.
26.
Wise GN, Dollery CT, Henkind P: The Retinal Circulation . Hagerstown, Md, Harper & Row Publishers Inc, 1971, p 47.
27.
Goldberg MF, Tso MOM:  Rubeosis iridis and glaucoma associated with sickle cell retinopathy: A light and electron microscopic study . Ophthalmology 1978;85:1028-1041.Article
28.
Shakib M, Oliveira F:  Study on developing retinal vessels: X. Formation of the basement membrane and differentiation of intramural pericytes . Br J Ophthalmol 1966;50:124-133.Article
29.
Archer DB, Gardner TA:  Experimental inner retinal ischemia and the blood-retinal barriers , in Cunha-Vaz JG (ed): The Blood-Retinal Barriers . New York, Plenum Press Inc, 1980, pp 279-299.
×