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March 1983

Intravitreous Miconazole-Reply

Arch Ophthalmol. 1983;101(3):487. doi:10.1001/archopht.1983.01040010487041

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In Reply.  —We thank Dr Peyman for his remarks on our article. However, we find it surprising that, in unpublished data, he noted no in vivo effect of miconazole in the management of experimental C albicans endophthalmitis. Although our article did not deal with the efficacy of miconazole, we find his observations contrary to those of others. For example, Jones1 proved the efficacy of miconazole and ketaconazole in the treatment of various forms of oculomycosis. Foster2 reported that miconazole and ketaconazole were effective in the treatment of Candida and Aspergillus corneal ulcers. In their research Osato et al3 found ketaconazole to be effective in the treatment of Candida endophthalmitis produced in animals. The finding of Osato et al is particularly interesting because of Peyman's comment that flucytosine and ketaconazole lack effectiveness against Candida in vivo.We would like to add that miconazole has been an important addition to

Jones BR:  Principles in the management of oculomycosis . Am J Ophthalmol 1975;79:719-751.
Foster CS:  Miconazole therapy for keratomycosis . Am J Ophthalmol 1981;91:622-629.
Osato MS, Vgland DN, Bruberg TH, et al:  Ketoconazole therapy of endogenous Candida albicans endophthalmitis . Invest Ophthalmol Vis Sci 1980;19:113.