[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
May 1983

Idoxuridine-Induced Conjunctival Cicatrization

Author Affiliations

From the Division of Ophthalmology, University Hospitals of Cleveland (Dr Lass); and the Cornea Service, Massachusetts Eye and Ear Infirmary, Boston (Drs Thoft and Dohlman).

Arch Ophthalmol. 1983;101(5):747-750. doi:10.1001/archopht.1983.01040010747009

• Four patients had idoxuridine-induced conjunctival cicatrization similar to ocular cicatricial pemphigoid develop, but in the treated eye only. Three of the four patients had chronic, recurrent herpes simplex epithelial and stromal keratitis. The fourth patient had Sjögren's syndrome. All received idoxuridine (0.1% drops and/or 0.5% ointment) and topical corticosteroids from one to 3½ years. Substantial morbidity resulted that included visual loss, stromal ulceration, corneal scarring, and keratinization. Conjunctival biopsy specimens showed cicatrization with a mixed inflammatory cell reaction and absence of goblet cells. Results of direct immunofluorescent microscopy of the conjunctiva were either negative or nonspecific for autoantibody. No circulating autoantibody was detected in any of the four patients.

Wilson F:  Adverse external ocular effects of topical ophthalmic medications . Surv Ophthalmol 1979;24:57-88.Article
Binder P:  Herpes simplex keratitis . Surv Ophthalmol 1977;21:313-331.Article
Jones B:  Prospects in treating viral disease of the eye . Trans Ophthalmol Soc UK 1967;87:537-579.
Laibson P:  Current therapy of herpes simplex virus infection of the cornea . Int Ophthalmol Clin 1973;13:39-52.
Harrist T, Mihm M:  Cutaneous immunopathology: Diagnostic use of direct and indirect immunofluorescence techniques in dermatologic disease . Hum Pathol 1979;10:625-653.Article
Thygeson P, Dawson C:  Pseudotrachoma caused by molluscum contagiosum virus and various clinical irritants . Excerpta Medica Int Congr Serv 1970;222:1894-1897.
Ostler HB, Okumoto M, Daniels T, et al:  Drug induced cicatrization of the conjunctiva , in O'Connor GR (ed): Immunologic Diseases of the Mucous Membranes . New York, Masson Publishing USA Inc, 1980, pp 149-158.
Duke-Elder S (ed): System of Ophthalmology . St Louis, CV Mosby Co, 1965, vol 8:  Diseases of the Outer Eye , p 504.
Mondino B, Ross A, Rabin B, et al:  Autoimmune phenomenon in ocular cicatricial pemphigoid . Am J Ophthalmol 1977;83:443-450.
Coster D, Welham R:  Herpetic canalicular obstruction . Br J Ophthalmol 1979;63:259-262.Article
Harris G, Hyndiuk R, Fox M, et al:  Herpetic canalicular obstruction . Arch Ophthalmol 1981;99:282-283.Article
Patterson A, Jones B:  The management of ocular herpes . Trans Ophthalmol Soc UK 1967;87:59-84.
Prusoff W, Goz B:  Potential mechanisms of action of antiviral agents . Fed Proc 1973;32:1679-1687.
Grant WM: Toxicology of the Eye , ed 2. Springfield, Ill, Charles C Thomas Publisher, 1974, p 587.
Pavan-Langston D, Lass J, Hettinger M, et al:  Acyclovir and vidarabine in therapy of ulcerative herpes simplex keratitis: A cooperative masked clinical trial . Am J Ophthalmol 1981;92:829-835.