[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
July 1983

Ocular Manifestations of Graft-v-Host Disease

Author Affiliations

From the Fred Hutchinson Cancer Research Center, Seattle.

Arch Ophthalmol. 1983;101(7):1080-1084. doi:10.1001/archopht.1983.01040020082014

• Graft-v-host disease is the major complication of bone marrow transplantation for the leukemias and aplastic anemia. In the clinical evaluation of eye problems of patients with acute graft-v-host disease, findings reveal a disease process of keratoconjunctivitis that appears to represent a specific pathologic eye syndrome in which the conjunctivae and occasionally the cornea represent an immunologic target of graft-v-host disease. Additional studies of eye problems of chronic graft-v-host disease reveal the persistent nature of keratitis sicca and the morbid sequelae of the immunoincompetent patient.

Thomas ED, Storb R, Clift RA, et al:  Bone marrow transplantation . N Engl J Med 1975;292:832-843, 895-902.Article
Storb R, Thomas ED, Buckner CD, et al:  Marrow transplantation in 30 'untransfused' patients with severe aplastic anemia . Ann Intern Med 1980;92:30-36.Article
Thomas ED, Buckner CD, Clift RA, et al:  Marrow transplantation for acute nonlymphoblastic leukemia in first remission . N Engl J Med 1979;301:597-599.Article
Sullivan KM, Shulman HM, Storb R, et al:  Chronic graft-versus-host disease in 52 patients: Adverse natural course and successful treatment with combination immunosuppression . Blood 1981;57:267-276.
Shulman HM, Sale GE, Lerner KG, et al:  Chronic cutaneous graft-versus-host disease in man . Am J Pathol 1980;91:545-570.
Shulman HM, Sullivan KM, Weiden PL, et al:  Chronic graft-versus-host syndrome in man: A long-term clinico-pathologic study of 20 Seattle patients . Am J Med 1980;69:204-217.Article
Graze PR, Gale RP:  Chronic graft-versus-host disease: A syndrome of disordered immunity . Am J Med 1979;66:611-620.Article
Gratwohl AA, Moutsopoulos HM, Chused TM, et al:  Sjögren-type syndrome after allogeneic bone-marrow transplantation . Ann Intern Med 1977;87:703-706.Article
Lawley TJ, Peck GL, Moutsopoulos HM, et al:  Scleroderma: Sjögren-like syndrome, and chronic graft-versus-host disease . Ann Intern Med 1977;87:707-709.Article
Duke Elder S: System of Ophthalmology . St Louis, CV Mosby Co, 1963, vol 8, p 132.
Sale GE, Shulman HM, Schubert MM, et al:  Oral and ophthalmic pathology of graft-versus-host disease in man: Predictive value of the lip biopsy . Hum Pathol 1981;12:1022-1029.Article
Beschorner WE, Tutschka PJ, Santos GW:  Sequential morphology of GVHD in rat radiation chimera . Clin Immunol Immunopathol 1982; 22:204-224.Article