• Graft-v-host disease is the major complication of bone marrow transplantation for the leukemias and aplastic anemia. In the clinical evaluation of eye problems of patients with acute graft-v-host disease, findings reveal a disease process of keratoconjunctivitis that appears to represent a specific pathologic eye syndrome in which the conjunctivae and occasionally the cornea represent an immunologic target of graft-v-host disease. Additional studies of eye problems of chronic graft-v-host disease reveal the persistent nature of keratitis sicca and the morbid sequelae of the immunoincompetent patient.
Jack MK, Jack GM, Sale GE, Shulman HM, Sullivan KM. Ocular Manifestations of Graft-v-Host Disease. Arch Ophthalmol. 1983;101(7):1080-1084. doi:10.1001/archopht.1983.01040020082014