[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
December 1983

Combination Therapy for Dendritic Keratitis With Acyclovir and α-Interferon

Author Affiliations

From the Royal Netherlands Eye Hospital, Utrecht, Holland (Drs de Koning and van Bijsterveld), and the National Public Health Institute, Helsinki (Dr Cantell).

Arch Ophthalmol. 1983;101(12):1866-1868. doi:10.1001/archopht.1983.01040020868006

• Fifty-nine patients with superficial herpetic keratitis were treated with 3% acyclovir ointment five times a day in combination with α-interferon (30 million IU/mL) or albumin-placebo once a day in a stratified double-masked clinical trial. All patients had minimal wiping of the superficial lesion to isolate virus. The healing time of the corneal ulcers was substantially lower with the combination of acyclovir and interferon than with the combination of acyclovir and placebo. Only minor toxic effects were observed. The combination of acyclovir and interferon appears to be the best presently known treatment for dendritic keratitis.

Kaufman HE, Martola EL, Dohlman C:  Use of 5-iodo-2′-deoxyuridine (IDU) in treatment of herpes simplex keratitis . Arch Ophthalmol 1962; 68:235-239.Article
Wellings PC, Awdry PN, Bors FH, et al:  Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers . Am J Ophthalmol 1972;73:932-942.
Pavan-Langston D, Dohlman C:  A double-blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis . Am J Ophthalmol 1972;74:81-88.
Jones BR, Fison PN, Cobo LM, et al:  Efficacy of acycloguanosine (Wellcome 248U) against herpes simplex corneal ulcers . Lancet 1979;1:243-244.Article
Collum LMT, Benedict-Smith A, Hillary IB:  Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration . Br J Ophthalmol 1980;64:766-769.Article
McGill J, Tormey P, Walker CB:  Comparative trial of acyclovir and adenine arabinoside in the treatment of herpes simplex corneal ulcers . Br J Ophthalmol 1981;65:610-613.Article
Pavan-Langston D, Lass J, Hettinger M, et al:  Acyclovir and vidarabine in the treatment of ulcerative herpes simplex keratitis . Am J Ophthalmol 1981;92:829-835.
Yeakley WR, Laibson PR, Michelson MA, et al:  A double-controlled evaluation of acyclovir and vidarabine for the treatment of herpes simplex epithelial keratitis . Trans Am Ophthalmol Soc 1981;79:168-177.
Jones BR:  Human interferon in topical therapy of herpetic keratitis , in Sundmacher R (ed): Herpetic Eye Diseases . Munich, Bergmann, 1981, pp 395-400.
Kaufman HE, Meyer RF, Laibson PR, et al:  Human leucocyte interferon for prevention of recurrences of herpetic keratitis . J Infect Dis 1976;133:165-168.Article
Sundmacher R, Cantell K, Neumann-Haefelin D:  Combination therapy for dendritic keratitis with trifluorothymidine and interferon . Lancet 1978;2:687.Article
De Koning EWJ, van Bijsterveld OP, Cantell K:  Combination therapy for dendritic keratitis with human leucocyte interferon and trifluorothymidine . Br J Ophthalmol 1982;66:509-512.Article
Cantell K, Hirvonen S, Koistinen V:  Partial purification of human leucocyte interferon on a large scale . Methods Enzymol 1981;78:499-505.
Van Bijsterveld OP, Post H:  Trifluorothymidine versus adenine arabinoside in the treatment of herpes simplex keratitis . Br J Ophthalmol 1980;64:33-36.Article