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January 1984

Forskolin, a Potent Adenylate Cyclase Activator, Lowers Rabbit Intraocular Pressure

Author Affiliations

From the Department of Ophthalmology, California College of Medicine, University of California, Irvine.

Arch Ophthalmol. 1984;102(1):146-148. doi:10.1001/archopht.1984.01040030124051

• To our knowledge, this is the first report of a topically applied, specific adenylate cyclase activator that reduces intraocular pressure. Forskolin, a novel adenylate cyclase activator, is reported to increase cyclic adenosine monophosphate (AMP) in intact cells. Cyclic AMP levels are increased with various antiglaucoma agents. Intraocular pressure in rabbits was significantly reduced with two concentrations of forskolin, 0.1% and 0.05%. Ocular hypertension was noted with 0.5% and 0.2%. No change in IOP was noted with 0.01% forskolin. The IOP lowering with 0.1% and 0.05% forskolin lasted approximately six hours. Mild, transient conjunctival chemosis was noted in the doses that decreased IOP. The contralateral control eye showed decreases in IOP, but the differences between control and tested eyes were significant by the Student's paired t test.

Chunekar KC: Bhav Prakash Nighantu , Hindi translation. Chaukhamba Vidya Bhavan, Banaras, India, 1960, p 86.
Sharma PV: Dravya Guna Vigyan: Parts II and III . Chaukhamba Vidaya Bhavan, Banaras, India, 1956, p 273.
Linder E, Dohadwalla A, Bhattacharya B:  Positive inotropic and blood pressure lowering activity in a diterpene derivative isolated from coleus forskolin: Forskolin . Arzneimittelforsch 1978;28:284-289.
Robinson GA, Butcher RW, Sutherland EW: Cyclic AMP . New York, Academic Press Inc, 1971.
Metzger H, Linder E:  The positive inotropicacting forskolin: A potent adenylatecyclase activator . Arzneimittelforsch 1981;31:1248-1250.
Siegl A, Daly J, Smith J:  Inhibition of aggregation and stimulation of cyclic AMP generation in intact human platelets by the diterpene forskolin . Mol Pharmacol 1982;21:680-687.
Neufeld A, Jampol L, Sears M:  Cyclic-AMP in the aqueous humor: The effects of adrenergic agents . Exp Eye Res 1972;14:242-250.Article
Neufeld A, Sears M:  Adenosine 3′,5′monophosphate analogue increases the outflow facility of the primate eye . Invest Ophthalmol Vis Sci 1975;14:688-689.
Seamon KB, Padgett W, Daly J: Forskolin:  Unique diterpene activator of adenylate cyclase in membranes and in intact cells . Proc Natl Acad Sci USA 1981;78:3363-3367.Article
Gregory D, Sears M, Bausher L, et al:  Intraocular pressure and aqueous flow are decreased by cholera toxin . Invest Ophthalmol Vis Sci 1981;20:371-381.
Eakins KE:  Prostaglandin and non-prostaglandin mediated breakdown of the blood-aqueous barrier . Exp Eye Res 1977;25( (suppl) ):483-498.Article