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Article
July 1984

Hematoporphyrin Derivative Photoradiation Therapy in Managing Nevoid Basal-Cell Carcinoma SyndromeA Preliminary Report

Author Affiliations

From the Division of Oculoplastics, Orbital and Oncology Services, Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City.

Arch Ophthalmol. 1984;102(7):990-994. doi:10.1001/archopht.1984.01040030792018
Abstract

• Hematoporphyrin derivative (HpD) is a photodynamically active dye that is preferentially retained by malignant tissues and initiates a cytotoxic reaction when exposed to red light. Normal tissues adjacent to a tumor retain HpD to a lesser degree and are thus spared damage from the light-induced reaction. We describe the treatment of 40 basal-cell carcinomas in three patients with nevoid basal-cell carcinoma syndrome. All treated lesions showed disappearance of clinically apparent tumor within four to six weeks, and there was no damage to surrounding skin. Thirty-three lesions (82.5%) showed complete response on biopsy findings, while seven showed residual tumor cells. The recurrence rate was 10.8%, with the follow-up ranging from 12 to 14 months. Tumor response was related to the total light dose delivered and the size and location of the tumor.

References
1.
Dougherty TJ, Kaufman JE, Goldfarb A, et al:  Photoradiation therapy for the treatment of malignant tumors . Cancer Res 1978;38:2628-2635.
2.
Lipson R, Baldes E, Olsen A:  The use of a derivative of hematoporphyrin in tumor detection . JNCI 1961;26:1-8.
3.
Kinsey JH, Cortese DA, Sanderson DR:  Detection of hematoporphyrin fluorescence during fiberoptic bronchoscopy to localize early bronchogenic carcinoma . Mayo Clin Proc 1978; 53:594-600.
4.
Carpenter RJ, Neel HB, Ryan RJ, et al:  Tumor fluorescence with hematoporphyrin derivative . Ann Otol Rhinol Laryngol 1977; 86:661-666.
5.
Weishaupt KR, Gomer CJ, Dougherty TJ:  Identification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor . Cancer Res 1976;36:2326-2329.
6.
Dubbelman TMAR, DeGoeij AFPM, Van Steveninck J:  Photodynamic effects of protoporphyrin on human erythrocytes: Nature of the cross-linking of membrane proteins . Biochem Biophys Acta 1978;511:141-151.Article
7.
Kessel D:  Effects of photoactivated porphyrins in cell surface properties . Biochem Soc Trans 1977;5:139-140.
8.
Buettner GR, Oberley LW:  The apparent production of superoxide and hydroxyl radicals by hematoporphyrin and light as seen by spin-trapping . FEBS Lett 1980;121:161-164.Article
9.
Moan J, Smedshammer L, Christensen T:  Photodynamic effects on human cells exposed to light in the presence of hematoporphyrin-pH effects . Cancer Lett 1980;9:327-332.Article
10.
Gomer CJ:  DNA damage and repair in CHO cells following hematoporphyrin photoradiation . Cancer Lett 1980;11:161-167.Article
11.
Gomer CJ, Rucker N, Banerjee A, et al:  Comparison of mutagenicity and induction of sister chromatid exchange in Chinese hamster cells exposed to hematoporphyrin derivative photoradiation, ionizing radiation, or ultraviolet radiation . Cancer Res 1983;43:2622-2627.
12.
Kessel D, Dougherty TJ (eds): Advances in Experimental Medicine and Biology. New York, Plenum Publishing Corp, 1983, vol 160: Porphyrin Photosensitization , pp 53-62.
13.
Cortese DA, Kinsey JH, Woolner LB, et al:  Clinical application of a new endoscopic technique for detection of in situ bronchial carcinoma . Mayo Clin Proc 1979;54:635-641.
14.
Benson RC, Farrow GM, Kinsey JH, et al:  Detection and localization of in situ carcinoma of the bladder with hematoporphyrin derivative . Mayo Clin Proc 1982;57:548-555.
15.
Kelly JF, Snell ME:  Hematoporphyrin derivative: A possible aid in the diagnosis and therapy of carcinoma of the bladder . J Urol 1976; 115:150-151.
16.
Dougherty TJ, Lawrence G, Kaufman JE, et al:  Photoradiation in the treatment of recurrent breast carcinoma . JNCI 1979;62:231-237.
17.
Forbes IJ, Cowled PA, Leong AS, et al:  Phototherapy of human tumours using haematoporphyrin derivative . Med J Aust 1980;2:489-493.
18.
Dougherty TJ:  Photoradiation therapy for cutaneous and subcutaneous malignancies . J Invest Dermatol 1981;77:122-124.Article
19.
Laws ER, Cortese DA, Kinsey JH, et al:  photoradiation therapy in the treatment of malignant brain tumors: A phase I (feasibility) study . Neurosurgery 1981;9:672-677.Article
20.
Hayata Y, Kato H, Konaka C, et al:  Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer . Chest 1982; 81:269-277.Article
21.
Cortese DA, Kinsey JH:  Endoscopic management of lung cancer with hematoporphyrin derivative phototherapy . Mayo Clin Proc 1982; 57:543-547.
22.
Ward BG, Forbes IJ, Cowled PA, et al:  The treatment of vaginal recurrence of gynecologic malignancy with phototherapy following hematoporphyrin derivative pretreatment . Am J Obstet Gynecol 1982;142:356-357.
23.
Dahlman A, Wile AG, burns RG, et al:  Laser photoradiation therapy of cancer . Cancer Res 1983;43:430-434.
24.
Anderson DE, Taylor WB, Falls HF, et al:  The nevoid basal cell carcinoma syndrome . Am J Hum Genet 1967;19:12-22.
25.
Howell JB, Cro MR:  The basal cell nevus: Its relationship to multiple cutaneous cancers and associated anomalies of development . Arch Dermatol 1959;79:67-80.Article
26.
Southwick GJ, Schwartz RJ:  The basal cell nevus syndrome: Disasters occurring among a series of 36 patients . Cancer 1979;44:2294-2305.Article
27.
Doiron DR: Photophysics and instrumentation. Program and abstracts of the Clayton Foundation Symposium on Porphyrin Localization and Treatment of Tumors, Santa Barbara, Calif, April 24-28, 1983.
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