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Article
February 1985

Lipopolysaccharide Tolerance Inhibits Eye InflammationII. Preliminary Studies on the Mechanism

Author Affiliations

From the Department of Pathology, University of California, San Francisco (Dr Howes), and the Kuzell Institute for Arthritis Research, Medical Research Institute of San Francisco at Pacific Presbyterian Medical Center (Dr Rosenbaum).

Arch Ophthalmol. 1985;103(2):261-265. doi:10.1001/archopht.1985.01050020113032
Abstract

• The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.

References
1.
Greisman SE, Hornick RB:  Mechanisms of endotoxin tolerance with special reference to man . J Infect Dis 1973;128( (suppl) ):257-268.Article
2.
Milner KC:  Patterns of tolerance to endotoxin . J Infect Dis 1973;128( (suppl) ):227-237.Article
3.
Ayo C:  Toxic ocular reaction: New property of Shwartzman toxins . J Immunol 1943;46:113-125.
4.
Cousins SW, Rosenbaum JT, Guss RB, et al:  Ocular albumin fluorophotometric quantitation of endotoxin induced vascular permeability . Infect Immun 1982;36:730-736.
5.
Levene RZ, Breinen GM:  Ocular effects of endotoxin . Arch Ophthalmol 1957;61:568-577.Article
6.
Howes EL Jr, Goldyne ME, Perez HD, et al:  Lipopolysaccharide tolerance inhibits ocular inflammation: I. Reduced immune complex or lipopolysaccharide effects . Arch Ophthalmol 1985;103:257-260.Article
7.
Bhattacherjee P, Phylactos A:  Increased prostaglandin synthetase activity in inflamed tissues of the rabbit eye . Eur J Pharmacol 1977; 44:75-80.Article
8.
Bhattacherjee P, Hammond B, Salmon JA, et al:  Chemotactic response to some arachidonic acid lipoxygenase products in the rabbit eye . Eur J Pharmacol 1981;73:21-28.Article
9.
Al-Ghadyan A, Mead A, Sears M:  Increased pressure after paracentesis of the rabbit eye is completely accounted for by prostaglandin synthesis and release plus pupillary blockade . Invest Ophthalmol 1979;18:361-365.
10.
Neufeld AH, Jampol LM, Sears ML:  Aspirin prevents the disruption of the blood aqueous barrier in the rabbit eye . Nature 1972;238:158-159.Article
11.
Neufeld AH, Sears ML:  The site of action of prostaglandin E2 on the disruption of blood-aqueous barrier in the rabbit eye . Exp Eye Res 1973;17:445-448.Article
12.
Howes EL Jr, McKay DG:  Comparison of the ocular effects of circulating endotoxin and immune complexes: Role of vasoactive amines . J Immunol 1975;114:734-737.
13.
Howes EL Jr, Char DH, Christensen M:  Aqueous immune complexes in immunogenic uveitis . Invest Ophthalmol 1972;23:715-718.
14.
Jensen PR, Aronson SB, Pollycove M, et al:  Mechanisms of host response in the eye: III. Interocular protein transfer . Arch Ophthalmol 1967;77:814-817.Article
15.
Crawford JP, Movat HZ, Ranadine NS, et al:  Pathways to inflammation induced by immune complexes: Development of the Arthus reaction . Fed Proc 1982;41:2583-2587.
16.
Eakins KE, Whitelocke RAF, Perkins ES, et al:  Release of prostaglandins in ocular inflammation in rabbits . Nature New Biol 1972;239:248-249.Article
17.
Wedmore C, Williams TJ:  Control of vascular permeability by polymorphonuclear leukocytes in inflammation . Nature 1981;289:646-650.Article
18.
Kopaniak MM, Movat HZ:  Kinetics of acute inflammation induced by Escherichia coli in rabbits: II. The effect of hyperimmunization, complement depletion, and depletion of leukocytes . Am J Pathol 1983;110:13-29.
19.
Williams RN, Paterson CA:  PMN accumulation in aqueous humor and iris-ciliary body during intraocular inflammation . Invest Ophthalmol Vis Sci 1984;25:105-108.
20.
Rosenbaum JT, Howes EL Jr, Goldstein IM:  Endotoxin tolerance diminishes some antiinflammatory effects of endotoxin , abstracted. Fed Proc 1982;41:558.
21.
Wong KL, Howes EL Jr:  Intraocular injection of prostaglandins: Modification of response to circulating bacterial endotoxin . Arch Ophthalmol 1983;101:275-279.Article
22.
Bito LZ:  The effects of experimental uveitis on anterior uveal prostaglandin transport and aqueous humor composition . Invest Ophthalmol Vis Sci 1974;13:959-966.
23.
Howes EL Jr, Rosenbaum JT, Cruse VK:  Ocular inflammation induced by intravitreal endotoxin (LPS) is enhanced in LPS tolerant rabbits , abstracted. Invest Ophthalmol Vis Sci 1984;25( (suppl) ):29.
24.
Howes EL Jr, Wong KL, Hartiala KT, et al: Complement and polymorphonuclear leukocytes do not determine the vascular permeability induced by intraocular LPS. Am J Pathol, in press.
25.
Skarnes RC, Braan SK, Hull SS, et al:  Role of prostaglandin E in the biphasic fever response to endotoxin . J Exp Med 1981;154:112-122.Article
26.
Sraer JD, Moulonguet-Doleris L, Delarue F, et al:  Prostaglandin synthesis by glomeruli isolated from rats with glycerol-induced acute renal failure . Circ Res 1981;49:775-783.Article
27.
Andrews C, Nolan JP, Venuto RC:  Effects of endotoxin tolerance on the hemodynamic changes associated with glycerol administration . Nephron 1981;28:141-144.Article
28.
Wahl LM, Rosenstreich DL, Glove LM, et al:  Defective prostaglandin synthesis by C3H/HeJ macrophage stimulated with endotoxin preparations . Infect Immun 1979;23:8-13.
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