[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
March 1985

Role of Lensectomy and Posterior Capsule in Movement of Tracers from Vitreous to Aqueous

Author Affiliations

From the Center for Vitreoretinal Research, The Wilmer Ophthalmological Institute, The Johns Hopkins University, Baltimore.

Arch Ophthalmol. 1985;103(3):420-421. doi:10.1001/archopht.1985.01050030116034

• The rate of movement of 20,000- and 70,000-dalton dextran from vitreous to aqueous was determined after extracapsular lensectomy in rabbits with an intact posterior capsule. Dextran was injected into the vitreous, and 3.5 hours later the aqueous concentration of 20,000-dalton dextran was 10.3-fold greater in the aphakic than the phakic eye. The aqueous concentration of the 70,000-dalton dextran was 3.9-fold greater in the aphakic eye after 3.5 hours. Thus, extracapsular lensectomy with an intact posterior capsule increases the rate of movement of 20,000- and 70,000-dalton dextran from the vitreous to the anterior chamber. In addition, the movement of tracers from vitreous to aqueous is increased further when the posterior capsule is opened.

Blankenship GW:  The lens influence on diabetic vitrectomy results . Arch Ophthalmol 1980;98:2196-2198.Article
Rice TA, Michels RG, Maguire M, et al:  The effect of lensectomy on the incidence of iris neovascularization and neovascular glaucoma after vitrectomy for diabetic retinopathy . Am J Ophthalmol 1983;95:1-11.
Aiello L, Martin W, Liang G:  Neovascular glaucoma and vitreous hemorrhage following cataract surgery in patients with diabetes mellitus . Ophthalmology 1983;90:814-820.Article
Williams GA, Eisenstein R, Schumacher B, et al:  Inhibitor of vascular endothelial cell growth in the lens . Am J Ophthalmol 1984;97:366-371.
Blankenship G, Cortez R, Machemer R:  The lens and pars plana vitrectomy for diabetic retinopathy complications . Arch Ophthalmol 1979; 97:1263-1267.Article
Schachat AP, Oyakawa RT, Michels RG, et al:  Complications of vitreous surgery for diabetic retinopathy: II. Postoperative complications . Ophthalmology 1983;90:522-530.Article
Algvere P, Bill A:  Drainage of microspheres and RBCs from the vitreous of aphakic and phakic eyes . Arch Ophthalmol 1979;97:1333-1336.Article
Glaser BM, D'Amore PA, Michels RG, et al:  Demonstration of vasoproliferative activity from mammalian retina . J Cell Biol 1980;298-304.
D'Amore PA, Glaser BM, Brunson SK, et al:  Angiogenic activity from bovine retina:partial purification and characterization . Proc Natl Acad Sci USA 1981;78:3068-3072.Article
Thompson JT, Glaser BM:  Effect of lensectomy on the movement of tracers from vitreous to aqueous . Arch Ophthalmol 1984;104:1077-1078.Article
Moffat K, Blumenkranz M, Hernandez E, et al:  The influence of the lens capsule in vitreous surgery . Invest Ophthalmol Vis Sci 1983; 24( (suppl) ):240.
Culotta FJ, Blumenkranz MS, Hernandez E, et al:  Effect of neodymium:YAG laser capsulotomy on rubeosis iridis . Invest Ophthalmol Vis Sci 1984;25( (suppl) ):246.
Beyer TL, Vogler G, Sharma D, et al:  Protective barrier effect on the posterior lens capsule in exogenous bacterial endopthalmitis . Invest Ophthalmol Vis Sci 25:108-112, 1984.