[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
May 1985

Effects of Intravitreal Administration of Steroids on Experimental Subretinal Neovascularization in the Subhuman Primate

Author Affiliations

From the Department of Ophthalmology, University of Southern California School of Medicine (Drs Ishibashi, Miki, and Ryan, and Ms Patterson), and the Estelle Doheny Eye Foundation (Dr Sorgente), Los Angeles.

Arch Ophthalmol. 1985;103(5):708-711. doi:10.1001/archopht.1985.01050050100026

• To elucidate the role of inflammation in the occurrence of experimental subretinal neovascularization caused by highintensity laser photocoagulation, we investigated the effects of vitreal infusion of steroids on laser lesions in a primate model. Dexamethasone, with or without triamcinolone, was infused continuously for two weeks through an indwelling cannula system. The animals were followed up clinically for up to eight weeks. The frequency of subretinal neovascularization in the steroid-treated animals was significantly lower than that in a control group of untreated animals. Although steroids have multiple effects, these results suggest that the inflammatory response, possibly macrophage infiltration, may plan an important role in the occurrence of subretinal neovascularization in our experimental model.

Gass JDM:  Pathogenesis of disciform detachment of the neuroepithelium: I. General concepts and classifications . Am J Ophthalmol 1967;63:573-585.
Patz A, Fine SL, Finkelstein D, et al:  Diseases of the macula: The diagnosis and management of choroidal neovascularization . Trans Am Acad Ophthalmol Otolaryngol 1977;83:468-475.
Ryan SJ:  The development of an experimental model of subretinal neovascularization in disciform macular degeneration . Trans Am Ophthalmol Soc 1979;77:707-745.
Ryan SJ:  Subretinal neovascularization: Natural history of an experimental model . Arch Ophthalmol 1982;100:1804-1809.Article
Polverini PJ, Cotran PS, Gimbrone MA Jr, et al:  Activated macrophages induce vascular proliferation . Nature 1977;269:804-806.Article
Miki K, Ohkuma H, Ryan SJ:  A method for chronic drug infusion into the eye . Jpn J Ophthalmol 1984;28:140-146.
Schoefl GI:  Studies on inflammation: III. Growing capillaries: Their structure and permeability . Virchows Arch Pathol Anat Physiol 1963; 337:97-141.Article
Sarks SH:  Ageing and degeneration in the macular region: A clinico-pathological study . Br J Ophthalmol 1976;60:324-341.Article
McAuslan BR, Gole GA:  Cellular and molecular mechanisms in angiogenesis . Trans Ophthalmol Soc UK 1980;100:354-358.
Grindle CFJ, Marshall J:  Ageing changes in Bruch's membrane and their functional implications . Trans Ophthalmol Soc UK 1978;98:172-175.
Sarks SH, van Driel D, Maxwell L, et al:  Softening of drusen and subretinal neovascularization . Trans Ophthalmol Soc UK 1980;100:414-422.
Penfold P, Killingsworth M, Sarks SH:  An ultrastructural study of the role of leucocytes and fibroblasts in the breakdown of Bruch's membrane . Aust J Ophthalmol 1984;12:23-31.Article
BenEzra D:  Neovasculogenic ability of prostaglandins, growth factors, and synthetic chemoattractants . Am J Ophthalmol 1978;86:455-461.
Lerche W:  Licht-und elektronenmikroskopische Beobachtungen uber die Einwirkung von Argonlaserstrahlen auf des Pigmentepithel der anliegenden menschlichen Retina . Graefes Arch Clin Exp Ophthalmol 1973;187:215-228.Article
Ishikawa Y, Ikui H:  Electron-microscopic studies on retinal repair in the monkey after xenon photocoagulation: I. Cellular responses in the early stage of repair . Jpn J Ophthalmol 1974; 18:334-349.
Wallow HH:  Repair of the pigment epithelial barrier following photocoagulation . Arch Ophthalmol 1984;102:126-135.Article
Werb Z:  Biochemical actions of glucocorticoids on macrophages in culture: Specific inhibition of elastase, collagenase, and plasminogen . J Exp Med 1978;147:1695-1712.Article
Werb Z, Foley R, Munck A:  Interaction of glucocorticoids with macrophages: Identification of glucocorticoid receptors in monocytes and macrophages . J Exp Med 1978;147:1684-1694.Article
Vernon-Roberts B:  The effects of steroid hormones on macrophage activity . Int Rev Cytol 1969;25:131-159.
Leibovich SJ, Ross R:  The role of the macrophage in wound repair: A study with hydrocortisone and antimacrophage serum . Am J Pathol 1975;78:71-99.
Fisher LB, Maibach HI:  The effect of corticosteroids on human epidermal mitotic activity . Arch Dermatol 1971;103:39-44.Article
Longenecker JP, Kilty LA, Johnson LK:  Glucocorticoid influence on growth of vascular wall cells in culture . J Cell Physiol 1982;113:197-202.Article