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— Dr Wand suggests that the intact anterior hyaloid membrane face may be a barrier to the movement of macromolecules from the vitreous to aqueous in addition to the posterior capsule and lens-zonular diaphragm. We cannot determine the relative contributions of the vitreous, anterior hyaloid membrane, and posterior capsule and zonules as a barrier to the movement of macromolecules from the vitreous to aqueous in our rabbit model. The strength of the hyaloideocapsular ligament in the rabbit makes a rent in the anterior hyaloid membrane very likely when a posterior capsulotomy is performed. We have considered isolating the posterior capsule and testing the diffusion of macromolecules across the posterior capsule in a Boyden chamber, as suggested by Wand, but have found this technique difficult in the rabbit, given the strong attachment of the anterior hyaloid membrane to the posterior capsule.A recent study by Poliner and associates1
Thompson JT, Glaser BM. Hyaloid Membrane vs Posterior Capsule as a Protective Barrier-Reply. Arch Ophthalmol. 1985;103(8):1112-1113. doi:10.1001/archopht.1985.01050080024008