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October 1985

The Effects of Subconjunctival Miconazole in the Treatment of Experimental Candida Keratitis in Rabbits

Author Affiliations

From the LSU Eye Center, Louisiana State University Medical Center and School of Medicine, New Orleans (Drs Ishibashi and Kaufman) and the Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan (Dr Ishibashi).

Arch Ophthalmol. 1985;103(10):1570-1573. doi:10.1001/archopht.1985.01050100146038

• Subconjunctival miconazole (1.2 mg/day for three weeks) produced a marked clinical improvement in the ocular lesions produced by inoculation with Candida albicans in a group of ten rabbits. Clinical scores of affected eyes were significantly lower in this treated group than in a control group of ten untreated rabbits. All cultures of corneal scrapings were negative on the 15th day after inoculation in the treated group, while three cultures were still positive at the end of the experiment (day 21) in the control group. Histopathologic examination showed considerably less-severe inflammatory changes in the eyes of treated animals compared with those of control animals.

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