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October 1986

BW B759U for Cytomegalovirus Retinitis: Intraocular Drug Penetration

Author Affiliations

Baltimore; Research Triangle Park, NC; Baltimore

Arch Ophthalmol. 1986;104(10):1436-1437. doi:10.1001/archopht.1986.01050220030009

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To the Editor.  —Cytomegalovirus (CMV) infection of the retina is a well-recognized complication of immunosuppression or immunodeficiency. Recently, a new investigational agent for the treatment of CMV infection, 9-(1,3-dihydroxy-2-propoxymethyl)guanine (BW B759U, Burroughs Wellcome Co, Research Triangle Park, NC), has become available.1 We report CMV retinitis in a patient undergoing bone marrow transplantation, the response to therapy with BW B759U, and the subretinal fluid levels of that drug at the time of retinal reattachment surgery.

Report of a Case.  —A 13-year-old male bone marrow transplant patient was seen at the Wilmer Ophthalmological Institute,Baltimore, for retinitis. The patient was well until October 1983, when he was diagnosed as having acute myelogenous leukemia. His leukemia went into remission with chemotherapy, and in January 1984, he underwent an allogeneic bone marrow transplant. The patient never developed either acute or chronic graft-vs-host disease. In June 1984, he was found to have Candida esophagitis,

Palestine AG, Stevens G Jr, Lane HC, et al:  Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine . Am J Ophthalmol 1986;101:95-101.
Hirst LW, Jabs DA, Tutschka PJ, et al:  The eye in bone marrow transplantation: I. Clinical study . Arch Ophthalmol 1983;101:580-584.Article
Mar EC, Cheng YC, Huang ES:  Effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine on human cytomegalovirus replication in vitro . Antimicrob Agents Chemother 1983;24:518-521.Article