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September 1987

Experimental Doxorubicin MyopathyA Permanent Treatment for Eyelid Spasms?

Author Affiliations

From the Department of Ophthalmology, University of Minnesota, Minneapolis.

Arch Ophthalmol. 1987;105(9):1265-1268. doi:10.1001/archopht.1987.01060090123041

• Doxorubicin may effect a more permanent chemomyectomy and chemodenervation (by retrograde "suicide transport") of the orbicularis oculi muscle than the chemodenervation produced by botulinum A toxin used for the treatment of blepharospasm. Graded doses (0.4 mg and 1.0 mg) of doxorubicin hydrochloride (2 mg/mL) were injected into the eyelids and antecubital and popliteal skin of rabbits in an attempt to evaluate the drug's efficacy and safety. Histologic changes in the orbicularis oculi muscle included necrosis and decreased mass. The results are promising because the eyelids appear to be more resistant than other skin regions to the development of tissue necrosis. Moreover, doxorubicin might not be excessively toxic in the treatment of eyelid cancer.

Scott AB, Kennedy RA, Stubbs HA:  Botulinum A toxin injection as a treatment for blepharospasm . Arch Ophthalmol 1985;103:347-350.Article
Adriamycin package insert, revised. Adria Laboratories Inc, Dublin, Ohio, June 1983.
Zorzato F, Salviati G, Facchinetti T, et al:  Doxorubicin induces calcium release from terminal cisternae of skeletal muscle: A study on isolated sarcoplasmic reticulum and chemically skinned fibers . J Biol Chem 1985;260:7349-7355.
Yamamoto T, Iwasaki Y, Konno H:  Retrograde axoplasmic transport of Adriamycin . Neurology 1984;34:1299-1304.Article
Bigotte L, Olsson Y:  Retrograde transport of doxorubicin (Adriamycin) in peripheral nerves of mice . Neurosci Lett 1982;32:217-221.Article
Bigotte L, Olsson Y:  Cytotoxic effects of Adriamycin on mouse hypoglossal neurons following retrograde axonal transport from the tongue . Acta Neuropathol 1983;61:161-168.Article
Cohen M:  Amelioration of Adriamycin skin necrosis: An experimental study . Cancer Treat Rep 1979;63:1003-1004.
Sonneveld P, Wassenaar HA, Nooter K:  Long persistence of doxorubicin in human skin after extravasation . Cancer Treat Rep 1984;68:895-896.
Bleicher JN, Haynes W, Massop D, et al:  The delineation of Adriamycin extravasation using fluorescence microscopy . Plast Reconstr Surg 1984;74:114-116.Article
Cho ES:  Toxic effects of Adriamycin on the ganglia of the peripheral nervous system: A neuropathological study . J Neuropathol Exp Neurol 1977;36:907-915.Article
Smith B:  Damage to the intrinsic cardiac neurons by rubidomycin (Daunorubicin) . Br Heart J 1969;31:607-609.Article
Mamakos M:  Recall phenomenon or severe skin and muscle necrosis following Adriamycin extravasation in the hand . Int Surg 1984;69:73-74.
Luxenberg M, Guthrie T:  Chemotherapy of basal cell and squamous cell carcinoma of the eyelids and periorbital tissues . Ophthalmology 1986;93:504-510.Article
Sikic BI, Ehsan MN, Harker WG, et al:  Dissociation of antitumor potency anthracycline cardiotoxicity in a doxorubicin analog . Science 1985;228:1544-1546.Article
Tone H, Kiyosaki T, Cuthbert JA, et al:  Acute local irritative effect of (2"R) 41-O-tetrahydropyranyladriamycin, a new antitumor antibiotic . Jpn J Antibiot 1968;39:569-581.