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March 1988

Melanoma Arising De Novo Over a 16-Month Period

Author Affiliations

From the Department of Ophthalmology, Harvard Medical School, and the Howe Laboratory of Ophthalmology and the David G. Cogan Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary, Boston (Drs Sahel and Albert); and the Ophthalmic Consultants of Boston (Drs Pesavento and Frederick).

Arch Ophthalmol. 1988;106(3):381-385. doi:10.1001/archopht.1988.01060130407031

• Choroidal melanoma is widely regarded as a slow-growing tumor. We report herein the first documented case, to our knowledge, of a choroidal melanoma present in an eye in which examination 16 months earlier disclosed no tumor. On gross examination following enucleation, the largest tumor diameter at the base was 19 mm and the height was 11 mm. The implications as to the growth rate and the precursor lesions of choroidal melanomas are discussed.

McLean IW, Foster WD, Zimmerman LE, et al:  Inferred natural history of uveal melanomas . Invest Ophthalmol Vis Sci 1980;19:760-770.
Gass JDM:  Observation of suspected choroidal and ciliary body melanomas for evidence of growth prior to enucleation . Ophthalmology 1980;87:523-528.Article
Zimmerman LE:  Malignant melanoma of the uveal tract , in Spencer WH: Ophthalmic Pathology: An Atlas and Textbook . Philadelphia, WB Saunders Co, 1986, vol 3, pp 2072-2139.
Gass JDM:  Comparison of uveal melanoma growth rates with mitotic index and mortality . Arch Ophthalmol 1985;103:924-931.Article
Manschot WA, Van Peperzeel HA:  Choroidal melanoma: Enucleation or observation? A new approach . Arch Ophthalmol 1980;98:71-77.Article
Collins VP, Leffler RK, Twey H:  Observations on growth rates of human tumors . AJR 1956;76:988-1000.
Pardee AB:  Principles of cancer biology: Biochemistry and cell biology , in De Vita VT Jr, Hellman S, Rosenbert JA (eds): Cancer, Principles and Practice of Oncology , ed 2. Philadelphia, JB Lippincott, 1985, vol 1, pp 7-8.
De Schweinitz GE, Shumway EA:  Concerning melanoma of the choroid with report of one case of this character and of another exhibiting a pigmented melanoma of the choroid early in its development . Trans Am Ophthalmol Soc 1905;10:439-451.
Yanoff M, Zimmerman LE:  Histogenesis of malignant melanomas of the uvea: II. Relationship of uveal nevi to malignant melanoma . Cancer 1967;20:493-507.Article
Tamler E:  A clinical study of choroidal nevi: A follow-up report . Arch Ophthalmol 1970;84:29-32.Article
Ganley JP, Comstock GW:  Benign nevi and malignant melanoma of the choroid . Am J Ophthalmol 1973;76:19-25.
Albert DM, Gaasterland DF, Caldwell JBH, et al:  Bilateral metastatic choroidal melanoma, nevi, and cavernous degeneration: Involvement of the optic nerve head . Arch Ophthalmol 1972;87:39-47.Article
Albert DM, Lahav M, Packer S, et al:  Histogenesis of malignant melanomas of the uvea: Occurrence of nevuslike structures in experimental choroidal tumors . Arch Ophthalmol 1976;92:318-323.Article
Lever WF, Schaumberg-Lever G: Histopathology of the Skin , ed 6. Philadelphia, JB Lippincott, 1983, p 707.
Fine SL:  Do I take the eye out or leave it in? Arch Ophthalmol 1986;104:653-654.Article