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April 1988

Latent Disseminated Blastomycosis With Choroidal Involvement

Author Affiliations

From the Department of Ophthalmology, Medical College of Wisconsin, Milwaukee (Drs Lewis and Aaberg), and the Department of Ophthalmology, University of Wisconsin, Madison (Dr Stevens). Dr Fary is in private practice in Fort Atkinson, Wis. Dr Lewis is now with the Wilmer Ophthalmological Institute, Baltimore. Dr Aaberg is now with Emory University, Atlanta.

Arch Ophthalmol. 1988;106(4):527-530. doi:10.1001/archopht.1988.01060130573040

• A 36-year-old man developed blurred vision and a cough five months after traveling to an area from where a large out-break of acute blastomycosis had been reported. Examination revealed a left choroidal lesion in the macular region, skin lesions on the right calf, and a left lung apical infiltrate. Histopathologic examination of the skin lesion demonstrated a granulomatous inflammation and broad-based, budding yeast characteristic of Blastomyces dermatitidis. Amphotericin B therapy produced a rapid resolution of both choroidal and pulmonary lesions. During a six-month follow-up, there was no evidence of recurrence.

Busey JF:  Blastomycosis: I. A review of 198 collected cases in Veterans Administration hospitals . Am Rev Respir Dis 1964;89:659-672.
Witorsch P, Utz JP:  North American blastomycosis: A study of 40 patients . Medicine 1968;47:169-200.Article
Sarosi GA, Hammerma KJ, Tosh FE, et al:  Clinical features of acute pulmonary blastomycosis . N Engl J Med 1974;290:540-543.Article
Dismukes WE:  Blastomycosis: Leave it to beaver . N Engl J Med 1986;314:575-577.Article
Churchill F, Stober AM:  A case of systemic blastomycosis . Arch Intern Med 1914;13:568.Article
Schwartz VJ:  Intraocular blastomycosis . Arch Ophthalmol 1931;5:581-589.Article
Cassady JV:  Uveal blastomycosis . Arch Ophthalmol 1946;35:84-97.Article
Sinskey RM, Anderson WB:  Miliary blastomycosis with metastatic spread to the posterior uvea of both eyes . Arch Ophthalmol 1955;54:602-604.Article
Font RL, Spaulding AG, Green WR:  Endogenous mycotic panophthalmitis caused by Blastomyces dermatitidis: Report of a case and review of the literature . Arch Ophthalmol 1967;77:217-222.Article
Rodriguez MM, Laibson P, Kaplan W:  Exogenous mycotic keratitis caused by Blastomyces dermatitidis . Am J Ophthalmol 1973;75:782-789.
Vida L, Moel SA:  Systemic North American blastomycosis with orbital involvement . Am J Ophthalmol 1974;77:240-242.
Bond WI, Sanders CV, Joffe L, et al:  Presumed blastomycosis endophthalmitis . Ann Ophthalmol 1982;14:1183-1188.
Barr CC, Gamel JW:  Blastomycosis of the eyelid . Arch Ophthalmol 1986;104:96-97.Article
Marcus DF, Bovino JA, Burton TC:  Sarcoid granuloma of the choroid . Ophthalmology 1982;89:1326-1330.Article
Cameron ME, Harrison A:  Ocular cryptococcosis in Australia: With a report of two further cases . Med J Aust 1970;1:935.
Klein BS, Vergeront JM, Weeks RJ, et al:  Isolation of Blastomyces dermatitidis in soil associated with a large outbreak of blastomycosis in Wisconsin . N Engl J Med 1986;314:529-534.Article
National Institute for Allergy and Infectious Diseases Mycosis Study Group:  Treatment of blastomycosis and histoplasmosis with ketoconazole: Results of a prospective randomized clinical trial . Ann Intern Med 1985;103:861-872.Article
Bradsher RW, Rice DC, Abernathy RS:  Ketoconazole therapy for endemic blastomycosis . Ann Intern Med 1985;103:872-879.Article