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October 1988

Retinal Pigment Epithelial Cells in Culture Produce Retinal Vascular Mitogens

Author Affiliations

From the Surgical Vitreoretinal Unit, Moorfields Eye Hospital (Drs Wong and McLeod), and the Department of Clinical Ophthalmology, Institute of Ophthalmology (Drs Boulton and Marshall, Ms Bayly, and Mr Clark), London.

Arch Ophthalmol. 1988;106(10):1439-1443. doi:10.1001/archopht.1988.01060140603031

• Conditioned medium from human retinal pigment epithelial cells in culture significantly stimulated the proliferation of subcultured bovine retinal capillary endothelial cells, pericytes, and freshly isolated retinal microvessels. The vascular mitogenic activity enhanced that of retinal crude extract. No evidence emerged of an inhibitor of microvascular cellular proliferation produced by retinal pigment epithelial cells.

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