[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
February 1989

Vitreous Fluorophotometry in Carriers of Choroideremia and X-linked Retinitis Pigmentosa

Author Affiliations

From the Department of Ophthalmology, Eye and Ear Infirmary, University of Illinois College of Medicine at Chicago.

Arch Ophthalmol. 1989;107(2):209-212. doi:10.1001/archopht.1989.01070010215025

• The status of the blood-retinal barrier (BRB) in carriers of choroideremia and X-linked retinitis pigmentosa (XLRP) was determined by vitreous fluorophotometry (VF) and compared with that in female control subjects. Electroretinographic (ERG) amplitudes were measured to determine the overall functional integrity of retinal rods and cones. Comparison of the VF results showed an abnormal BRB in at least some carriers of XLRP, particularly those with peripheral fundus pigmentary changes, but not in carriers of choroideremia with even moderately extensive pigmentary changes. The abnormal BRB in XLRP carriers, with or without peripheral fundus pigmentary changes, was associated with at least moderate to moderately extensive reduction in scotopic ERG amplitudes, while the normal VF results in choroideremia carriers were associated with normal scotopic ERG amplitudes. However, in XLRP carriers, mild to modest reductions in ERG scotopic responses were seen in the presence of normal VF findings.

Fishman GA, Cunha-Vaz J, Salzano T:  Vitreous fluorophotometry in patients with retinitis pigmentosa . Arch Ophthalmol 1981;99:1202-1207.Article
Fishman GA, Rhee AJ, Blair NP:  Blood-retinal barrier function in patients with cone or cone-rod dystrophy . Arch Ophthalmol 1986;104:545-548.Article
Fishman GA, Cunha-Vaz JG, Travassos AC:  Vitreous fluorophotometry in patients with fundus flavimaculatus . Arch Ophthalmol 1982;100: 1086-1088.Article
Zeimer RC, Blair NP, Cunha-Vaz JG:  Vitreous fluorophotometry for clinical research: I. Description and evaluation of a new fluorophotometer . Arch Ophthalmol 1983;101:1753-1756.Article
Zeimer RC, Blair NP, Cunha-Vaz JG:  Vitreous fluorophotometry for clinical research: II. Methodology of data acquisition and processing . Arch Ophthalmol 1983;101:1757-1761.Article
Cunha-Vaz JG, Gray JR, Zeimer RC, et al:  Characterization of the early stages of diabetic retinopathy by vitreous fluorophotometry . Diabetes 1985;34:53-59.Article
Fishman GA, Buckman G, Van Every T:  Fundus flavimaculatus: A clinical classification . Doc Ophthalmol Proc Ser 1977;13:213-220.
Kirk RE: Experimental Design: Procedures for the Behavioral Science . Belmont, Calif, Wadsworth Publishers, 1982.
Sieving PA, Niffenegger JH, Berson EL:  Electroretinographic findings in selected pedigrees with choroideremia . Am J Ophthalmol 1986;101:361-367.
Gieser DK, Fishman GA, Cunha-Vaz JG:  X-linked recessive retinitis pigmentosa and vitreous fluorophotometry: A study of female heterozygotes . Arch Ophthalmol 1980;98:307-310.Article
Cunha-Vaz JG:  Vitreous fluorophotometry recordings in posterior segment disease . Graefes Arch Clin Exp Ophthalmol 1985;222:241-247.Article
Larsen M, Krogsaa B, Warburg M, et al:  Carriers of X-linked retinitis pigmentosa: A fluorophotometric determination of the permeability of the blood-retinal barrier . Ophthalmic Paediatr Genet 1986;7:21-28.Article