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Article
March 1989

Retinitis Pigmentosa and Branch Retinal Artery Occlusion With Anticardiolipin Antibody

Arch Ophthalmol. 1989;107(3):324. doi:10.1001/archopht.1989.01070010334013

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Abstract

To the Editor.  —Anticardiolipin (AC), an antiphospholipid antibody, has been associated with thrombosis in patients with systemic lupus erythematosus and other autoimmune disorders.1 Retinal arterial and venous occlusion has been reported in patients with AC antibodies,2 and with other antiphospholipid antibodies, such as the lupus anticoagulant or a false-positive VDRL test result. We found elevated IgG and IgM AC antibody levels in a man with retinitis pigmentosa (RP) who presented with unexplained branch retinal artery occlusion.

Report of a Case.  —A diagnosis of RP was made in a 34-year-old man with a two-year history of poor night vision. His visual acuity was 20/25 OU, and a fundus examination showed arteriolar attenuation and mild peripheral retinal pigmentary changes. A visual field examination revealed generalized constriction, and electroretinography showed extinguished responses bilaterally under scotopic and photopic conditions. His medical history was remarkable for the β-thalassemia trait, which was also present

References
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Harris EN, Chan JKH, Asherson RA, et al:  Thrombosis, recurrent fetal loss, and thrombocytopenia: Predictive value of the anticardiolipin antibody test . Arch Intern Med 1986;146:2153-2156.Article
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Pulido JS, Ward LM, Fishman GA, et al:  Antiphospholipid antibodies associated with retinal vascular disease . Retina 1987;7:215-218.Article
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Triplett DA, Brandt JT, Musgrave KA, et al:  The relationship between lupus anticoagulants and antibodies to phospholipid . JAMA 1988;259:550-554.Article
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Levine SR, Welch KMA:  Cerebrovascular ischemia associated with lupus anticoagulant . Stroke 1987;18:257-263.Article
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Chant SM, Heckenlively J, Meyers-Elliott RH:  Autoimmunity in hereditary retinal degeneration: I. Basic studies . Br J Ophthalmol 1985;69:19-24.Article
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