[Skip to Content]
[Skip to Content Landing]
May 1989

Kinetics of Intraocular GasesDisappearance of Air, Sulfur Hexafluoride, and Perfluoropropane After Pars Plana Vitrectomy

Author Affiliations

From the Department of Ophthalmology and Visual Science, Yale University, New Haven, Conn.

Arch Ophthalmol. 1989;107(5):687-691. doi:10.1001/archopht.1989.01070010705031

• Intraocular gas bubbles are an important source of internal tamponade for the treatment of retinal breaks in eyes requiring vitrectomy. The kinetics of disappearance of air, 20% sulfur hexafluoride, and 10% perfluoropropane were prospectively evaluated in 76 eyes undergoing pars plana vitrectomy. The absorption of each gas approximated a first-order kinetic equation with respect to bubble volume. The half-life of air was 1.6 days in phakic and 0.9 days in aphakic eyes. The half-life of 20% sulfur hexafluoride was 2.8 days in phakic and 2.4 days in aphakic eyes. The half-life of 10% perfluoropropane was 5.7 days in phakic, 4.5 days in aphakic, and 4.3 days in pseudophakic eyes. The difference in half-life among the three gases was significant. Intraocular gases had a shorter half-life in aphakic than in phakic eyes.

Matsuda M, Tano Y, Inaba M, Manabe R.  Corneal endothelial cell damage associated with intraocular gas tamponade during pars plana vitrectomy . Jpn J Ophthalmol . 1986;30:324-329.
Foulks GN, de Juan E, Hatchell DL, McAdoot T, Hardin J.  The effect of perfluoropropane on the cornea in rabbits and cats . Arch Ophthalmol . 1987;105:256-259.Article
Chang S, Lincoff HA, Coleman DJ, Fuchs W, Farber ME.  Perfluorocarbon gases in vitreous surgery . Ophthalmology . 1985;92:651-656.Article
Lincoff HA, Coleman DJ, Kreissig I, Richard G, Chang S, Wilcox LM.  The perfluorocarbon gases in the treatment of retinal detachment . Ophthalmology . 1983;90:546-551.Article
Fineberg E, Machemer R, Sullivan P, Norton EWD, Hamaski D, Anderson D.  Sulfur hexafluoride in owl monkey vitreous cavity . Am J Ophthalmol . 1975;79:67-76.
Lincoff A, Kreissig I.  Intravitreal behavior of perfluorocarbons . Dev Ophthalmol . 1981;2:17-23.
Parver LM, Lincoff H.  Mechanics of intraocular gas . Invest Ophthalmol Vis Sci . 1978;17:77-79.
Parver LM, Lincoff HA.  Geometry of intraocular gas used in retinal surgery . Mod Probl Ophthalmol . 1977;18:338-343.
Jacobs PM.  Intraocular gas measurement using A-scan ultrasound . Curr Eye Res . 1986;5:575-578.Article
Wong RF, Thompson JT.  Prediction of the kinetics of disappearance of sulfur hexafluoride and perfluoropropane intraocular gas bubbles . Ophthalmology . 1988;95:609-613.Article
Rowen JW.  Morphology and embryology . In: Francois J, Hollwich F, eds. Augenheilkunde in Klinik und Praxis . Stuttgart, West Germany: Georg Thieme Verlag; 1977.
Thompson JT, Michels RG.  Volume displacement of scleral buckles . Arch Ophthalmol . 1985;103:1822-1824.Article
Wilmer HA, Scammon RE.  Growth of the components of the human eyeball . Arch Ophthalmol . 1950;43:599-637.Article
Lincoff HA, Maisel JM, Lincoff A.  Intravitreal disappearance rates of four perfluorocarbon gases . Arch Ophthalmol . 1984;102:928-929.Article
Abrams GW, Edelhauser HF, Aaberg TM, Hamilton LH.  Dynamics of intravitreal sulfur hexafluoride gas . Invest Ophthalmol Vis Sci . 1974;13:863-868.
Lincoff HA, Mardirossian J, Lincoff A, Liggett P, Iwamoto T, Jakobiec F.  Intravitreal longevity of three perfluorocarbon gases . Arch Ophthalmol . 1980;98:1610-1611.Article
Lincoff HA, Kreissig I, Brodie S, Wilcox L.  Expanding gas bubbles for the repair of tears in the posterior pole . Graefes Arch Clin Exp Ophthalmol . 1982;219:193-197.Article
Peters MA, Abrams GW, Hamilton LH, Burke JM, Schrieber TM.  The nonexpansile, equilibrated concentration of perfluoropropane gas in the eye . Am J Ophthalmol . 1985;100:831-839.
Piiper J, Canfield RE, Rahn H.  Absorption of various inert gases from subcutaneous gas pockets in rats . J Appl Physiol . 1962;17:268-274.
Tenney SM, Carpenter FG, Rahn H.  Gas transfers in a sulfur hexafluoride pneumoperitoneum . J Appl Physiol . 1953;6:201-208.
Rucker RW, Tenney SM.  Inert gas exchange in subcutaneous gas pockets of airbreathing animals: theory and measurement . Respir Physiol . 1966;1:151-171.Article
Crittenden JJ, de Juan E, Tiedeman J.  Expansion of long-acting gas bubbles for intraocular use . Arch Ophthalmol . 1985;103:831-834.Article