[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
November 1989

Assessment of Diclofenac on Herpes Keratitis in Rabbit Eyes

Author Affiliations

From the Doheny Eye Institute and the Departments of Ophthalmology (Dr Trousdale) and Preventive Medicine (Dr Barlow), University of Southern California School of Medicine, Los Angeles, and Ciba-Geigy Pharmaceuticals Corp (Dr McGuigan), Summit, NJ.

Arch Ophthalmol. 1989;107(11):1664-1666. doi:10.1001/archopht.1989.01070020742039

• Topical diclofenac sodium is a nonsteroidal anti-inflammatory drug that is being developed for use in the control of postoperative and medical inflammation. A comparison was made of 0.1% diclofenac with 1% prednisolone sodium phosphate, 0.03% flurbiprofen, and a vehicle placebo in rabbit eyes with acute herpetic keratitis in a double-masked study. Maximum corneal epithelial involvement was observed in each group on day 6 postinoculation, and in eyes subsequently treated with prednisolone, the corneal epithelial involvement appeared to be more severe and to resolve more slowly. Conjunctivitis and corneal clouding peaked on days 6 to 7 for all treatment groups and remained most severe in the placebo-treated eyes, followed closely by those treated with prednisolone. The duration of virus shedding was the same for placebo-, flurbiprofen-, and diclofenactreated groups (50% or more were virus negative by day 10 or 11). Only prednisolone-treated eyes had an extended period of virus shedding, and the rabbit mortality rate in this group was slightly higher. It thus appears that topical diclofenac does not exacerbate acute herpes keratitis; diclofenac-treated eyes displayed less or at least no more severe disease than did the eyes treated with the other anti-inflammatory agents tested, and shedding of virus into tears was not prolonged.

Pavan-Langston D, Dohlman CH.  A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis . Am J Ophthalmol . 1972;74:81-88.
Kaufman HE, Nesburn AB, Maloney ED.  IDU therapy of herpes simplex . Arch Ophthalmol . 1962;67:583-591.Article
Pavan-Langston DR.  Ocular virus diseases . In: Galasso GJ, Merigan TC, Buchanan RA, eds. Antiviral Agents and Viral Diseases of Man . New York, NY: Raven Press; 1979:253-303.
Mondino BJ, Aizuss DH, Farley MK.  Steroids . In: Lamberts DW, Potter DE, eds. Clinical Ophthalmic Pharmacology . Boston, Mass: Little Brown & Co Inc; 1987:157-172.
Kaufman HE.  Herpetic keratitis . Invest Ophthalmol Vis Sci . 1978;17:941-957.
Kaufman HE, Martola EL, Dohlman CH.  Herpes simplex treatment with IDU and corticosteroids . Arch Ophthalmol . 1963;69:468-472.Article
Jones BR.  Prospects in treating viral disease of the eye . Trans Ophthalmol Soc UK . 1967;87:537-579.
Thygeson P, Hogan MJ, Kimura SJ.  Cortisone and hydrocortisone in ocular infections . Trans Am Acad Ophthalmol Otolaryngol . 1953;57:64-85.
Kaufman HE, Maloney ED.  Experimental herpes simplex keratitis: the effect of corticosteroids and epithelial curettage . Arch Ophthalmol . 1961;66:99-102.Article
Trousdale MD, Dunkel EC, Nesburn AB.  Effect of flurbiprofen on herpes simplex keratitis in rabbits . Invest Ophthalmol Vis Sci . 1980;19:267-270.
Kirk RE.  Experimental design . In: Procedures for the Behavioral Sciences . 2nd ed. Monterey, Calif: Brooks/Cole Publishing Co; 1982:489-569.
SAS Institute Inc. SAS/STAT Guide for Personal Computers . Cary, NC: SAS Institute; 1985.
Hong SCL, Levine L.  Inhibition of arachidonic acid release from cells and the biochemical action of anti-inflammatory corticosteroids . Proc Nati Acad Sci USA . 1976;73:1730-1734.Article
Blackwell GJ, Flower RJ.  Inhibition of phospholipase . Br Med Bull . 1983;39:260-264.
Hirata F, Schiffmann E, Venkatasubramanian K, Salomon D, Axelrod J.  A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids . Proc Nati Acad Sci USA . 1980;77:2533-2536.Article
Ku EC, Lee W, Kothari HV, Kimble EF, Liauw L, Tjan J.  The effects of diclofenac sodium on arachidonic acid metabolism . Semin Arthritis Rheum . 1985;15:36-41.Article
Baker DA, Thomas J.  The effect of prostaglandin E2 on the initial immune response to herpes simplex virus infection . Am J Obstet Gynecol . 1985;151:586-590.Article
Harbour DA, Blyth WA, Hill TJ.  Prostaglandins enhance spread of herpes simplex virus in cell cultures . J Gen Virol . 1978;41:87-95.Article