This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
Drug eruptions following therapy with antibiotics are commonly encountered in clinical practice. Many of these are considered secondary to circulating immune complexes (Gel and Coombs'1(p1351) type III hypersensitivity). I examined a patient who developed bilateral limbal hyperemia with peripheral corneal stromal and epithelial edema concurrent with a fever and rash after receiving oral cefaclor.
Report of a Case.
—A 45-year-old white man was referred to the Eye Institute, Milwaukee, Wis, with bilateral keratoconjunctivitis. He reported that 9 days previously, he had noted a painful swelling of his right preauricular region. Infectious parotitis was diagnosed at a walk-in clinic, and the patient was begun on treatment with oral cefaclor. After 2 days, a rash developed abruptly, beginning on the palms and spreading to diffusely involve the entire body. The cefaclor was discontinued; however, fever and eye pain developed that night. An ophthalmologist diagnosed conjunctivitis, and gentamicin drops were prescribed without
Platt LW. Bilateral Peripheral Corneal Edema After Cefaclor Therapy. Arch Ophthalmol. 1990;108(2):175. doi:10.1001/archopht.1990.01070040027014