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Article
May 1990

Sulfonamide Hypersensitivity and Acetazolamide

Author Affiliations

Aurora, Colo

Arch Ophthalmol. 1990;108(5):634-635. doi:10.1001/archopht.1990.01070070020005

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Abstract

To the Editor.  —Recently, a discussion arose among the physicians in our ophthalmology residency program regarding the use of acetazolamide (Diamox, Lederle Laboratories Pearl River, NY) in patients who report a "sulfa" allergy or hypersensitivity. Acetazolamide is a sulfonamide drug related to many other drugs of this class, including sulfamethoxazole, thiazide diuretics, and certain oral hypoglycemics. Although the majority of the staff ophthalmologists felt that "sulfa" allergy was a relative contraindication, a significant minority felt the use of acetazolamide in such a patient was absolutely contraindicated.A search of the MEDLINE and TOXLINE data bases (1966 through 1989) revealed more than 2000 references to acetazolamide, but not a single report of cross-sensitivity. In addition, the manufacturer of Diamox (Lederle Laboratories) has only a few reports on file of sulfonamide-type hypersensitivity reactions to Diamox. None of these reactions occurred in a patient with a well-documented history of "sulfa" allergy (written communication

References
1.
Moseley V, Baroody N.  Some observations on the use of acetazolamide (Diamox) as an oral diuretic in various edematous states and in uremia with hyperkalemia . Am Practitioner Digest Treatment . 1955;6:558-566.
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