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Ring-shaped infiltration of the corneal stroma, known as Wessely ring, is believed to result from intrastromal interaction of antigens, from either an infecting organism or altered corneal tissue, with antibodies diffusing into the cornea from the limbus.1 These complexes activate, complement, and subsequently attract inflammatory cells. We report a rare case of Behcet's disease in which both antibodies and antigens probably originated from the limbal vasculature. They diffused either separately or as an immune complex and precipitated in the stromal midperiphery, where an optimal concentration was achieved.
Report of a Case.
—A 16-year-old girl known to have Behcet's syndrome for 7 years was referred to our department. Her ophthalmic history consisted of recurrent nonpurulent conjunctivitis. Her visual acuity was 20/20 and the intraocular pressure was normal bilaterally. In the inferotemporal corneal periphery a semilunar stromal opacity was noted 1.5 mm from the limbus continuous with a stromal immune ring
Cohen S, Kremer I. Bilateral Corneal Immune Ring Opacity in Behcet's Syndrome. Arch Ophthalmol. 1991;109(3):324-325. doi:10.1001/archopht.1991.01080030026023