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—We appreciate the interest raised by our article. Liu et al cite our findings of an association between gout medications and mixed cataract, and summarize their previously reported findings among 53 patients using allopurinol. In our study, the use of any type of gout medication was investigated. Such use was found to be related to mixed cataract, our largest case group, but our results do not exclude associations of gout medications with individual cataract types.Dr Johnson comments on possible mechanisms to explain our finding of an association between use of eyeglasses before age 20 years and mixed cataract. Although our study obtained data on use of sunglasses, as suggested by Dr Johnson, no significant relationships with cataract were found. We agree with him that analyses exploring associations of risk factors with mixed cataract subgroups are of interest. Such analyses are ongoing and will be included in a
Leske MC, Grimson R, Hyman L, Wu S. Myopia and Cataract-Reply. Arch Ophthalmol. 1991;109(12):1636. doi:10.1001/archopht.1991.01080120014006