[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.211.41.181. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
February 1992

Glaucomatous Parapapillary AtrophyOccurrence and Correlations

Author Affiliations

From the Department of Ophthalmology and Eye Hospital, University of Erlangen-Nuremberg (Federal Republic of Germany).

Arch Ophthalmol. 1992;110(2):214-222. doi:10.1001/archopht.1992.01080140070030
Abstract

• Glaucomatous optic nerve damage is typically associated with intrapapillary changes, such as neuroretinal rim loss. In this study, parapapillary chorioretinal atrophy was evaluated in 691 normal eyes, 1081 glaucomatous eyes, and 31 eyes with ocular hypertension. It was significantly larger and occurred more often in the glaucomatous eyes (parapapillary atrophy area, 1.07±0.83 mm2) (mean±SD) than in the normal eyes (0.55±0.64 mm2) or in the eyes with ocular hypertension (0.55±0.37 mm2). These differences were significant also for eyes with moderate glaucomatous damage (0.86±0.62 mm2). Parapapillary chorioretinal atrophy was associated with shallow glaucomatous cupping, diffuse nerve fiber loss, a marked tessellated fundus, and only moderately elevated intraocular pressure. It increased with a decreasing neuroretinal rim area. It showed a spatial correlation to neuroretinal rim loss inside the optic disc. In unilateral glaucoma, it was larger in the affected eye than in the unaffected eye. Parapapillary chorioretinal atrophy is associated with glaucoma.

References
1.
Elschnig A.  Das Colobom am Sehnerveneintritte und der Conus nach unten . Arch Ophthalmol . 1900;51:391-430.
2.
Elschnig A.  Der normale Sehnerveneintritt des menschlichen Auges . Denkschrift der kaiserlichen Akademie der Wissenschaften Wien, Mathematisch Naturwissenschafttiche . 1901;70:219-310.
3.
Bücklers M.  Anatomische Untersuchung über die Beziehung zwischen der senilen und myopischen circumpapillären Aderhautatrophie: unter Beifügen eines Falles von hochgradiger Anisometropie . Arch Ophthalmol . 1929;121:243-283.
4.
Primrose J.  The incidence of the peripapillary halo glaucomatosus . Eye . 1971;89:585-588.
5.
Primrose J.  Early signs of the glaucomatous disc . Br J Ophthalmol . 1971;55:820-825.Article
6.
Hayreh SS.  Blood supply of the optic nerve head and its role in optic atrophy, glaucoma and oedema of the optic disc . Br J Ophthalmol . 1969;53:721-748.Article
7.
Raitta C, Sarmela T.  Fluorescein angiography of the optic disc and the peripapillary area in chronic glaucoma . Acta Ophthalmol (Copenh) . 1970;48:303-308.Article
8.
Wilensky JT, Kolker AE.  Peripapillary changes in glaucoma . Am J Ophthalmol . 1976;81:341-345.
9.
Primrose J.  Peripapillary changes in glaucoma . Am J Ophthalmol . 1977;83:930-931.
10.
Naumann GOH.  Glaukome und Hypotonie-Syndrome . In: Naumann GOH, ed. Pathologie des Auges . New York, NY: Springer-Verlag NY Inc; 1980:792-793.
11.
Laatikainen L.  Fluorescein angiographic studies of the peripapillary and perilimbal regions in simple, capsular and low-tension glaucoma . Acta Ophthalmol Suppl (Copenh) . 1981;111:1-83.
12.
Anderson DR.  Correlation of the peripapillary damage with the disc anatomy and field abnormalities in glaucoma . Doc Ophthalmol . 1983;35:1-10.
13.
Heijl A, Samander C.  Peripapillary atrophy and glaucomatous visual field defects . Doc Ophthalmol . 1985;42:403-407.
14.
Airaksinen PJ, Juvala PA, Tuulonen A, Alanko AI, Valkonen R, Tuohino A.  Change of peripapillary atrophy in glaucoma . In: Krieglstein GK, ed. Glaucoma Update III . New York, NY: Springer-Verlag NY Inc; 1987:97-102.
15.
Nevarez J, Rockwood EJ, Anderson DR.  The configuration of peripapillary tissue in unilateral glaucoma . Arch Ophthalmol . 1988;106:901-903.Article
16.
Rockwood EJ, Anderson DR.  Acquired peripapillary changes and progression in glaucoma . Graefes Arch Clin Exp Ophthalmol . 1988;226:510-515.Article
17.
Buus DR, Anderson DR.  Peripapillary crescents and halos in normal-tension glaucoma and ocular hypertension . Ophthalmology . 1989;96:16-19.Article
18.
Kasner O, Feuer WJ, Anderson DR.  Possibly reduced prevalence of peripapillary crescents in ocular hypertension . Can J Ophthalmol . 1989;24:211-215.
19.
Fantes FE, Anderson DR.  Clinical histologic correlation of human peripapillary anatomy . Ophthalmology . 1989;96:20-25.Article
20.
Jonas JB, Nhung XN, Gusek GC, Naumann GOH.  The parapapillary chorio-retinal atrophy in normal and glaucoma eyes, I: morphometric data . Invest Ophthalmol Vis Sci . 1989;30:908-918.
21.
Jonas JB, Naumann GOH.  Parapapillary chorio-retinal atrophy in normal and glaucoma eyes, II: correlations . Invest Ophthalmol Vis Sci . 1989;30:919-926.
22.
Fernández MC, Jonas JB, Naumann GOH.  Parapapilläre chorioretinale Atrophie in Augen mit flacher glaukomatöser Papillenexkavation . Fortschr Ophthalmol . 1990;87:457-460.
23.
Jonas JB, Königsreuther KA, Naumann GOH. Optic disc histomorphometry in normal and glaucomatous eyes, II: parapapillary region. Graefes Arch Clin Exp Ophthalmol. In press.
24.
Jonas JB, Gusek GC, Fernandez MC.  Correlation of the blind spot size to the area of the optic disc and parapapillary atrophy . Am J Ophthalmol . 1991;111:559-565.
25.
Stürmer J, Schroedel C, Rappl W.  Low-background-brightness, static SLO fundus-perimetry . Invest Ophthalmol Vis Sci . 1990;31( (suppl) ):504.
26.
Jonas JB, Gusek GC, Naumann GOH.  Optic disc morphometry in high myopia . Graefes Arch Clin Exp Ophthalmol . 1988;226:587-590.Article
27.
Littmann H.  Zur Bestimmung der wahren Grösse eines Objektes auf dem Hintergrund des lebenden Auges . Klin Monatsbl Augenheilkd . 1982;180:286-289.Article
28.
Betz P, Cramps F, Collignon-Brach J, Lavergne G, Weekers R.  Photographie stéréoscopique et photogrammétrie de l'éxcavation physiologique de la papille . J Fr Ophthalmol . 1981;4:193-203.
29.
Airaksinen PJ, Drance SM, Schulzer M.  Neuroretinal rim area in early glaucoma . Am J Ophthalmol . 1985;99:1-4.
30.
Jonas JB. Biomorphometrie des Nervus Opticus . Stuttgart, Federal Republic of Germany: Enke-Verlag; 1989.
31.
Airaksinen PJ, Drance SM, Douglas GR, Mawson DK, Nieminen H.  Diffuse and localized nerve fiber loss in glaucoma . Am J Ophthalmol . 1984;98:566-571.
32.
Jonas JB, Nguyen NX, Naumann GOH.  The retinal nerve fiber layer in normal eyes . Ophthalmology . 1989;96:627-632.Article
33.
Jonas JB, Nguyen NX, Strahwald H, Naumann GOH.  Die retinale Nervenfaserschicht in Normal- und Glaukomaugen, I: semiquantitative Daten von 398 Glaukomaugen . Klin Monastbl Augenheilkd . 1989;194:437-446.Article
34.
Jonas JB, Fernández MC, Naumann GOH.  Glaucomatous optic nerve damage in small discs with low cup/disk ratios . Ophthalmology . 1990;97:1211-1215.Article
35.
Jonas JB, Zach FM, Gusek GC, Naumann GOH.  Pseudoglaucomatous physiologic large cups . Am J Ophthalmol . 1989;107:137-144.
×