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June 1992

Fuchs' Heterochromic Iridocyclitis Is Not Associated With Ocular Toxoplasmosis

Author Affiliations

From the Department of Ophthalmo-Immunology, the Netherlands Ophthalmic Research Institute, Amsterdam (Drs La Hey, Rothova, and Kijlstra); Department of Ophthalmology, University of Amsterdam (Drs Rothova and Kijlstra); Eye Hospital, Rotterdam, the Netherlands (Drs Baarsma and de Vries); and National Institute of Public Health and Environmental Hygiene, Bilthoven, the Netherlands (Dr van Knapen).

Arch Ophthalmol. 1992;110(6):806-811. doi:10.1001/archopht.1992.01080180078032

• To analyze the association between Fuchs' heterochromic iridocyclitis (FHI) and toxoplasmosis, we performed ocular examinations and used various specific laboratory tests to establish a role for Toxoplasma gondii in the pathogenesis of FHI. Results were compared with those for other types of uveitis and healthy controls. Of the 88 patients with FHI, nine (10.2%) had toxoplasmosislike scars, but an association could not be proved by the indirect immunofluorescence antibody test or enzyme-linked immunosorbent assay, or by a test for cellular immunity to Toxoplasma antigen. Analysis of aqueous humor samples for Toxoplasma antibodies in patients with FHI also yielded negative results. On the basis of the negative results of these laboratory tests, we concluded that FHI is not associated with ocular toxoplasmosis.

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