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January 1993

Tissue Analysis From Two Patients With Premacular Hole Lesions

Author Affiliations

Huntington Beach, Calif

Arch Ophthalmol. 1993;111(1):22. doi:10.1001/archopht.1993.01090010024010

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To the Editor.  —In a recent clinicopathologic study Campochiaro et al1 reported immunocytochemical analysis of tissue obtained at the time of vitrectomy from two patients with "premacular hole lesions." I agree with their conclusion that this tissue is most likely posterior vitreous cortex removed from the premacular region. I furthermore agree with the contention that the cells in this tissue are likely responsible for the contractile forces that act on the macula, inducing striae, pucker, cysts, and in some cases, holes. The suggestion that these cells derive from retinal pigment epithelium and retinal glia is interesting but not conclusive. Although the authors invoke growth factor—stimulated cellular infiltration of the vitreous cortex as a possible mechanism, it is difficult to concur given that the retina is intact in the two cases that they studied. Furthermore, there is another equally plausible, if not more likely, explanation for these findings.Studies2-4

Campochiaro PA, van Niel E, Vinores SA.  Immunocytochemical labeling of cells in cortical vitreous from patients with premacular hole lesions . Arch Ophthalmol . 1992;110:371-377.Article
Hogan MJ, Alvarado JA, Weddel JE. Histology of the Human Eye: An Atlas and Textbook . Philadelphia, Pa: WB Saunders Co; 1971.
Grabner G, Baltz G, Forster O.  Macrophage-like properties of human hyalocytes . Invest Ophthalmol Vis Sci . 1980:19:333-340.
Sebag J.  Structure of the vitreous . In: The Vitreous: Structure, Function and Pathobiology . New York, NY: Springer-Verlag NY Inc; 1989:43-46.