[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.209.213. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 1993

Alcohol Use and Lens Opacities in the Beaver Dam Eye Study

Author Affiliations

From the Department of Ophthalmology, University of Wisconsin Medical School, Madison.

Arch Ophthalmol. 1993;111(1):113-117. doi:10.1001/archopht.1993.01090010117037
Abstract

• The relationship between alcohol use and lens opacities was examined in a large (N=4926) population-based study of adults aged 43 to 86 years in Beaver Dam, Wis. These data were collected from 1988 to 1990. Alcohol history was determined by a standardized questionnaire. Prevalence and severity of cataract were determined by masked grading of photographs obtained using a slit-lamp camera and retroillumination. A history of heavy drinking was related to more severe nuclear sclerotic, cortical, and posterior subcapsular opacities (odds ratios, 1.34, 1.38, and 1.57, respectively). These relationships remained after adjusting for other risk factors such as smoking. Moderate liquor consumption was associated with less severe nuclear sclerosis (odds ratio, 0.81). Participants who drank wine had less severe nuclear sclerosis (odds ratio, 0.84) and cortical opacities (odds ratio, 0.84) than those who did not. Increased consumption of beer was related to increased risk of cortical opacities.

References
1.
Clayton RM, Cuthbert J, Phillips CI, et al.  Analysis of individual cataract patients and their lenses: a progress report . Exp Eye Res . 1980;31:553-556.Article
2.
Harding JJ, van Heyningen R.  Beer, cigarettes and military work as risk factors for cataract . Dev Ophthalmol . 1989;17:13-16.
3.
Clayton RM, Cuthbert J, Duffy J, et al.  Some risk factors associated with cataract in SE Scotland: a pilot study . Trans Ophthal Soc U K . 1982;102:331-336.
4.
Harding JJ, van Heyningen R.  Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspirin-like analgesics and cyclopenthiazide . Br J Ophthalmol . 1988;72:809-814.Article
5.
Taylor HR.  The environment and the lens . Br J Ophthalmol . 1980;64:303-310.Article
6.
Flaye DE, Sullivan KN, Cullinan TR, Silver JH, Whitelocke RAF.  Cataracts and cigarette smoking: the city eye study . Eye . 1989;3:379-384.Article
7.
Klein R, Klein BEK, Linton KLP, DeMets DL.  The Beaver Dam Eye Study: visual acuity . Ophthalmology . 1991;98:1310-1315.Article
8.
Klein BEK, Magli YL, Neider MW, Klein R. Wisconsin System for Classification of Cataract From Photographs . Washington, DC: US Dept of Commerce; 1990. National Technical Information Service accession No. PB 90-138306.
9.
Klein BEK, Klein R, Linton KLP, Magli YL, Neider MW.  Assessment of cataracts from photographs in the Beaver Dam Eye Study . Ophthalmology . 1990;97:1428-1433.Article
10.
Klein BEK, Klein R, Linton KLP.  Prevalence of age-related lens opacities in a population: the Beaver Dam Eye Study . Ophthalmology . 1992;99:546-552.Article
11.
Agresti A. Analysis of Ordinal Categorical Data . New York, NY: John Wiley & Sons Inc; 1984:113-131.
12.
McCullagh P.  Regression models for ordinal data . J R Stat Soc B . 1980;42:109-142.
13.
SAS Institute Inc. SAS/STAT User's Guide: Version 6 . 4th ed. Cary, NC: SAS Institute Inc; 1989.
14.
Wallace RB, Colsher PL.  Enhancing the utility of quantity-frequency measures of alcohol consumption with assessments of problem drinking in a population study: a methodologic note . Ann Epidemiol . 1990;1:157-165.Article
15.
Graham S, Marshall J, Haughey B, et al.  Nutritional epidemiology of cancer of the esophagus . Am J Epidemiol . 1990;131:454-467.
16.
Tuyns AJ, Pequignot G, Gignoux M, Valla A.  Cancers of the digestive tract: alcohol and tobacco . Int J Cancer . 1982;30:9-11.Article
17.
Riboli E, Cornee J, Macquart-Moulin G, Kaaks R, Casagrande C.  Cancer and polyps of the colorectum and lifetime consumption of beer and other alcoholic beverages . Am J Epidemiol . 1991;134:157-166.
18.
Freudenheim JL, Graham S, Marshall JR, Haughey BP, Wilkinson G.  Life-time alcohol intake and risk of rectal cancer in western New York . Nutr Cancer . 1990;13:101-109.Article
19.
Leske MC, Chylack LT Jr, Wu SY.  The Lens Opacities Case-Control Study: risk factors for cataract . Arch Ophthalmol . 1991;109:224-251.
20.
DiPiro JT, Talkert RL, Hayes PE, Yee GC, Posey LM, eds. Pharmacotherapy: A Pathophysiologic Approach . New York, NY: Elsevier Science Publishing Co Inc; 1989:913.
21.
Kater RMH, Tobon F, Iber FL.  Increased rate of metabolism in alcoholic patients . JAMA . 1969;207:363-365.Article
22.
Baruh S, Sherman L, Kolodony HD, Singh AJ.  Fasting hypoglycemia . Med Clin North Am . 1973;57:1441-1462.
23.
Hayes SL, Pablo G, Radomski T, Palmer RS.  Ethanol and oral diazepam absorption . N Engl J Med . 1977;296:186-189.Article
24.
Lane EA, Guthrie S, Linnoila M.  Effects of ethanol on drug and metabolite pharmacokinetics . Clin Pharmacokinet . 1985;10:228-247.Article
25.
Krawitt EL.  Effect of ethanol ingestion on duodenal calcium transport . J Lab Clin Med . 1975;85:665-671.
×