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Article
February 1993

Baseline Visual Field Profile of Optic NeuritisThe Experience of the Optic Neuritis Treatment Trial

Author Affiliations

From the Department of Ophthalmology, University of California, Davis (Drs Keltner and Johnson and Mr Spurr), and the Department of Ophthalmology, University of South Florida, Tampa (Dr Beck).

Arch Ophthalmol. 1993;111(2):231-234. doi:10.1001/archopht.1993.01090020085029
Abstract

• The purpose of the present study was to determine the baseline visual field characteristics in 448 patients with acute optic neuritis who were entered into the Optic Neuritis Treatment Trial. The severity and pattern of visual field loss in both the affected and fellow eyes were classified. For affected eyes, diffuse visual field loss was present in 48.2% of eyes, central or centrocecal scotoma was present in 8.3% of eyes, altitudinal or other nervefiber bundle-type defects were present in 20.1% of eyes, and a variety of other defects were present in 23.4% of eyes. Visual field involvement was present in the fellow eye at baseline in 308 (68.8%) of the 448 patients. Evidence of a chiasmal or retrochiasmal visual field defect was present in 2.9% of the patients. Since a wide variety of visual field defects can occur with an acute attack of optic neuritis, the pattern of visual field loss is of limited utility in distinguishing optic neuritis from ischemic optic neuropathy and other optic nerve disorders. Asymptomatic visual field defects in the fellow eye are common.

References
1.
Beck RW, Cleary PA, Anderson M, et al.  A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis . N Engl J Med . 1992;326:581-588.Article
2.
Optic Neuritis Study Group.  The clinical profile of optic neuritis: experience of the Optic Neuritis Treatment Trial . Arch Ophthalmol . 1991;109:1673-1678.Article
3.
Keltner JL, Johnson CA, Beck RW, et al. Quality control functions of the Visual Field Reading Center (VFRC) for the Optic Neuritis Treatment Trial (ONTT). Controlled Clin Trials. In press.
4.
Berliner ML.  Acute optic neuritis in demyelinating diseases of the nervous system . Arch Ophthalmol . 1935;13:83-98.Article
5.
Carroll FD.  Retrobulbar neuritis: observations on one hundred cases . Arch Ophthalmol . 1940;24:44-54.Article
6.
Marshall D.  Ocular manifestations of multiple sclerosis and relationship to retrobulbar neuritis . Trans Am Ophthalmol Soc . 1950;48:487-525.
7.
Chamlin M.  Visual field changes in optic neuritis . Arch Ophthalmol . 1953;50:699-713.Article
8.
Hyllested K, Moller PM.  Follow-up on patients with a history of optic neuritis . Acta Ophthalmol (Copenh) . 1961;39:655-662.Article
9.
Nikoskelainen E.  Symptoms, signs and early course of optic neuritis . Acta Ophthalmol (Copenh) . 1975;53:254-272.Article
10.
Perkins GD, Rose FC.  Visual signs at presentation . In: Optic Neuritis and Its Differential Diagnosis . New York, NY: Oxford University Press Inc; 1979:43-73.
11.
Rizzo JF, Lessell S.  Optic neuritis and ischemic optic neuropathy: overlapping clinical profiles . Arch Ophthalmol . 1991;109:1668-1672.Article
12.
Trobe JD, Glaser JS.  Quantitative perimetry in compressive optic neuropathy and optic neuritis . Arch Ophthalmol . 1978;96:1210-1216.Article
13.
Berninger TA, Heider W.  Electrophysiology and perimetry in acute retrobulbar neuritis . Acta Ophthalmol (Copenh) . 1989;71:293-295.
14.
Gartner S.  Optic neuropathy in multiple sclerosis . Arch Ophthalmol .1953;50:718-726.Article
15.
Schlossman A, Philips CC.  Optic neuritis in relation to demyelinating diseases . Am J Ophthalmol . 1954;37:487-494.
16.
Traquair HM.  Acute retrobulbar neuritis affecting the optic chiasm and tract . Br J Ophthalmol . 1925;9:433-450.Article
17.
Savitsky N, Rangell L.  On homonymous hemianopia in multiple sclerosis . J Nerv Ment Dis . 1950;111:225-231.Article
18.
Vedel-Jensen N.  Optic tract neuritis in multiple sclerosis . Acta Ophthalmol (Copenh) . 1959;37:537-545.Article
19.
Boldt HA, Haerer AF, Tourtellotte WW, Henderson JW, De Jong RN.  Retrochiasmal visual field defects from multiple sclerosis . Arch Neurol . 1963;8:565-575.Article
20.
Ashworth B.  Chronic retrobulbar and chiasmal neuritis . Br J Ophthalmol . 1967;51:698-702.Article
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