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Mice HAVE traditionally been the animal of choice in mammalian genetic studies. They have been important both in increasing our understanding of basic genetic processes and as model systems to study specific human genetic diseases. Many fields in medicine have benefited greatly from such studies. Ophthalmology and visual science, however, with some notable exceptions such as the murine retinal degeneration and retinal degeneration slow mutations, have not, in general, placed much emphasis on murine genetic analyses. There are good reasons for this. Among other problems, mouse eyes are small and difficult to work with. There are structural differences between human and murine eyes, and the murine visual cortex and higher visual centers are not well developed. Despite these limitations, however, the development of new approaches that combine the power of traditional mouse genetics with modern molecular techniques make it certain that mouse studies will play an increasingly important role in
Zack DJ. Of Mice and Men: What Mice Can Teach Us About Human Ophthalmic Disease. Arch Ophthalmol. 1993;111(7):911-913. doi:10.1001/archopht.1993.01090070029013