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Article
September 1993

Central Serous Chorioretinopathy in Endogenous Hypercortisolism

Author Affiliations

From the Ophthalmic Genetics and Clinical Services Branch, National Eye Institute (Drs Bouzas, Scott, and Kaiser-Kupfer), and the Developmental Endocrinology Branch, National Institute of Child Health and Human Development (Drs Mastorakos and Chrousos), National Institutes of Health, Bethesda, Md.

Arch Ophthalmol. 1993;111(9):1229-1233. doi:10.1001/archopht.1993.01090090081024
Abstract

Objective:  To examine the potential association of central serous chorioretinopathy with endogenous hypercortisolism (Cushing's syndrome).

Design:  Ophthalmologic survey of consecutively admitted patients with endogenous Cushing's syndrome.

Setting:  An eye clinic of a research center (National Eye Institute, Bethesda, Md).

Patients:  Sixty consecutive patients with confirmed endogenous Cushing's syndrome.

Main Outcome Measures:  Findings from complete ophthalmologic evaluation.

Results:  Three (5%) of 60 patients had one or more episodes of appropriately documented central serous chorioretinopathy. In all cases, the episodes occurred during the period of hypercortisolism.

Conclusions:  Central serous chorioretinopathy is an uncommon manifestation of endogenous Cushing's syndrome. Since central serous chorioretinopathy has been associated with other hypercortisolemic states, we suggest that glucocorticoids may play a role in the development of this disease.

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