To document acute angle closure glaucoma temporally related to ingestion of oral imipramine hydrochloride.
Four patients with narrow angles received routinely prescribed doses of imipramine that triggered acute angle closure glaucoma.
Laser iridotomy was successful in all patients.
Psychoactive drugs should be prescribed cautiously in patients with known narrow angles and should be monitored by an ophthalmologist.
Ritch R, Krupin T, Henry C, Kurata F. Oral Imipramine and Acute Angle Closure Glaucoma. Arch Ophthalmol. 1994;112(1):67-68. doi:10.1001/archopht.1994.01090130077021