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We commend Dr Bloom for his thorough search of the literature dealing with the association of subretinal neovascular membranes and colobomas. Unfortunately, the entities described in his references 3 through 6 are colobomas of the retina and choroid, which occur because of defects in the closure of the fetal fissure.1,2 Both in their ophthalmoscopic appearance and in their developmental origin, these are quite different from the coloboma of the optic nerve reported by us and the related cavitary developmental lesions of the optic nerve (optic nerve "pits"; "morning glory syndrome") described in the references that we cited. By contrast with the colobomas of the retina and choroid that are described in all but one of the references cited by Dr Bloom, these defects are thought to be produced by abnormalities in the formation of the optic papilla.1,2 Perusal of the photographs in his references 3 through
Yedavally S, Frank RN. Peripapillary Subretinal Neovascularization Associated With Coloboma of the Optic Nerve-Reply. Arch Ophthalmol. 1994;112(2):154. doi:10.1001/archopht.1994.01090140028006