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May 1994

Calcific Band Keratopathy Associated With the Use of Topical Steroid-Phosphate Preparations

Author Affiliations

From the Department of Ophthalmology, University of Colorado School of Medicine, Denver (Drs Taravella, Forstot, and Underwood); the Department of Ophthalmology, Emory University, Atlanta, Ga (Dr Stulting); Madigan Army Medical Center, Tacoma, Wash (Dr Mader); and Syracuse (NY) Eye Center (Dr Weisenthal). The authors have no proprietary interest in any drugs mentioned in this article.

Arch Ophthalmol. 1994;112(5):608-613. doi:10.1001/archopht.1994.01090170052021

Objective:  To report a possible adverse effect of topical steroid-phosphate preparations and to identify factors that may contribute to the development of this effect.

Design:  The medical records of five patients who developed calcium deposition in the cornea were reviewed and analyzed for possible contributing factors.

Patients:  Five cases of calcium deposition in the cornea associated with the use of topical steroid-phosphate preparations are described. Scrapings from the cornea and/or specimens obtained at keratoplasty were available in all cases. These cases had the following characteristics in common: use of steroidphosphate preparations (n=5); multiple topical drops (n=5); penetrating keratoplasty (n=3); presence of epithelial defects (n=4); history of herpetic stromal keratitis (n=4); and history of iritis (n=3). A hypothesis explaining calcium deposition in association with steroid-phosphate preparations is presented.

Conclusions:  We recommend withdrawal of steroidphosphate preparations in patients who develop band keratopathy.

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