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Article
February 1995

Ultrastructure of Contusion Cataract

Author Affiliations

From the Department of Ophthalmology, University of Erlangen-Nürnberg, Erlangen, Germany.

Arch Ophthalmol. 1995;113(2):210-215. doi:10.1001/archopht.1995.01100020094037
Abstract

We investigated the histopathologic condition of four lenses with contusion rosette cataract by light and electron microscopy; periods between blunt trauma and cataract extraction varied from 4 months to 40 years. The initial morphologic changes appear to be the formation of intercellular vacuoles within the lens epithelium and the swelling of superficial cortical lens fibers. Signs of beginning fiber degeneration within the edematous zone include fragmentation of fiber cytoplasm into droplets and globules, formation of abnormal membrane arrangements, and enlargement of intercellular spaces. Late rosette opacities manifest as sharply demarcated layers of vacuolic degeneration in the deeper cortex. We suggest that in contusion cataract, a traumatically induced dysfunction of the lens epithelium leads to an edema of superficial cortical lens fibers that subsequently undergo degeneration and produce a localized and permanent lamellar zone of vacuolation. With time and with the formation of new clear lens cells, this layer becomes gradually compressed and displaced deeper into the cortex.

References
1.
Naumann GOH.  Lens . In: Naumann GOH, Apple DJ, eds. Pathology of the Eye . New York, NY: Springer-Verlag NY Inc; 1986:509-558.
2.
Duke-Elder S. System of Ophthalmology . London, England: Henry Krimpton; 1972;14(pt 1):121-141.
3.
Völcker HE.  Kontusionkatarakt und Linsenluxation . Fortschr Ophthalmol . 1984;81:308-311.
4.
Katsume Y, Yoshizuka M, Imayama H, Miyazaki M, Fujumoto S.  Electron microscopic study of an experimental contusion cataract of a Japanese monkey . Sangyo Ika Daigaku Zasshi . 1983;5:441-448.
5.
Wolter JR.  Coup-contrecoup mechanism of ocular injuries . Am J Ophthalmol . 1963;56:785-796.
6.
Rafferty NS.  Lens morphology . In: Maisei H, ed. The Ocular Lens . New York, NY: Marcel Dekker Inc; 1985:1-60.
7.
Spencer WH.  Lens . In: Spencer WH, Font RL, Green WR, Howes EL, Jakobiec FA, Zimmerman LE, eds. Ophthalmic Pathology . Philadelphia, Pa: WB Saunders Co; 1985;1:423-479.
8.
Pau H, Novotny GEK.  Ultrastructural investigations on anterior capsular cataract: cellular elements and their relationship to basement membrane and collagen synthesis . Graefes Arch Clin Exp Ophthalmol . 1985;223:41-46.Article
9.
Pau H, Novotny GEK.  Zur Metaplasie von Linsenepithelien in Fibroblasten . Fortschr Ophthalmol . 1985;82:132-138.
10.
Bleckmann H, Khodadadyan C, Schnoy N.  Lichtund Elektronenmikroskopie der humanen, anterioren Kataraktkapsel . Fortschr Ophthalmol . 1989;86:556-560.
11.
Kuwabara T.  The maturation of the lens cell: a morphologic study . Exp Eye Res . 1975;20:427-443.Article
12.
Broekhuyse RM, Kuhlmann ED, Jap PHK.  Lens membranes, IX: some characteristics of fiber membranes in relation to aging and cataract formation . Ophthalmic Res . 1979;11:423-428.Article
13.
Nagata M, Matsuura H, Fujinaga Y.  Ultrastructure of posterior subcapsular cataract in human lens . Ophthalmic Res . 1986;18:180-184.Article
14.
Dilley KJ, Bron AJ, Habgood JO.  Anterior polar and posterior subcapsular cataract in a patient with retinitis pigmentosa: a light-microscopic and ultrastructural study . Exp Eye Res . 1976;22:155-167.Article
15.
Jensen OA, Laursen AB.  Human senile cataract: light- and electron-microscopic studies of the morphology of the anterior lens structures, with special reference to anterior capsular/subcapsular opacity . Acta Ophthalmol . 1980;58:481-495.Article
16.
Hamai Y, Kuwabara T.  Early cytologic changes of Fraser cataract: an electron microscopic study . Invest Ophthalmol Vis Sci . 1975;14:517-527.
17.
Hamai Y, Fukui HN, Kuwabara T.  Morphology of hereditary mouse cataract . Exp Eye Res . 1974;18:537-546.Article
18.
Kinoshita JH.  Mechanisms initiating cataract formation . Invest Ophthalmol . 1974;13:713-724.
19.
Kuwabara T, Kinoshita JH, Cogan DG.  Electron microscopic study of galactose-induced cataract . Invest Ophthalmol Vis Sci . 1969;8:133-149.
20.
Sakuragawa M, Kuwabara T, Kinoshita JH, Hukui HN.  Swelling of the lens fibers . Exp Eye Res . 1975;21:381-394.Article
21.
Rafferty NS, Goossens W, March WF.  Ultrastructure of human traumatic cataract . Am J Ophthalmol . 1974;78:985-995.
22.
Al-Ghoul KJ, Costello MJ.  Morphological changes in human nuclear cataracts of late-onset diabetics . Exp Eye Res . 1993;57:469-486.Article
23.
De Gottrau P, Schlötzer-Schrehardt U, Dörfler S, Naumann GOH.  Congenital zonular cataract . Arch Ophthalmol . 1993;111:235-239.Article
24.
Costello MJ, Lane CW, Hatchell DL, Saloupis P, Cobo LM.  Ultrastructure of fiber cells and multilamellar inclusions in experimental diabetes . Invest Ophthalmol Vis Sci . 1993;34:2174-2185.
25.
Robison WG Jr, Houlder N, Kinoshita JH.  The role of lens epithelium in sugar cataract formation . Exp Eye Res . 1990;50:641-646.Article
26.
Jongbloed WL, Kalicharan D, Los LI, Worst JGF.  Study of the substructure of the Morgagni and Brunescens cataract with the TAO non-coating technique, I: Morgagni cataract . Doc Ophthalmol . 1992;82:151-160.Article
27.
Harding CV Jr, Susan SR, Lo W, Bobrowski WF, Maisel H, Chylack LT Jr.  The structure of the human cataractous lens . In: Maisei H, ed. The Ocular Lens . New York, NY: Marcel Dekker Inc; 1985:367-404.
28.
Philipson B.  Changes in the lens related to the reduction of transparency . Exp Eye Res . 1973;16:29-39.Article
29.
Anderson RS, Shearer TR.  Selenite nuclear cataractogenesis: a scanning electron microscope study . Curr Eye Res . 1992;11:1147-1160.Article
30.
Eshaghian J, March WF, Goossens W, Rafferty NS.  Ultrastructure of cataract in myotonic dystrophy . Invest Ophthalmol Vis Sci . 1978;17:289-293.
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