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The Central Vein Occlusion Study Group wishes to thank Dr Parodi for the thoughtful questions posed regarding our article in the Archives.1 We now address the questions as follows.Although macular edema is defined angiographically by the Central Vein Occlusion Study (CVOS), stereoscopic fundus photographs of the macula were required of all patients in group M at each visit. An analysis of these stereoscopic fundus photographs will be reported in a subsequent publication. There is, however, a major difference between the early changes of diabetic macular edema studied by the Early Treatment Diabetic Retinopathy Study and the more extensive macular edema found in most patients following central vein occlusion, which renders the stereoscopic fundus photographic evaluation somewhat less helpful.Eyes with macular nonperfusion were excluded from group M.The CVOS investigators are aware of the adverse impact of panretinal photocoagulation on diabetic macular edema. However, in the
Clarkson JG. Central Vein Occlusion and Laser Treatment-Reply. Arch Ophthalmol. 1995;113(5):555. doi:10.1001/archopht.1995.01100050017010