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March 1996

Ocular Tumoral CalcinosisA Clinicopathologic Study

Author Affiliations

From the Tennent Institute of Ophthalmology (Drs Ghanchi, Ramsay, and Barr), and the Department of Pathology (Drs Coupland and Lee), Western Infirmary, Glasgow, Scotland.

Arch Ophthalmol. 1996;114(3):341-345. doi:10.1001/archopht.1996.01100130337022

Tumoral calcinosis is a rare systemic disorder characterized by para-articular ectopic soft-tissue calcification. This case report describes the ophthalmic features (palpebral conjunctival calcific nodules, the white limbal girdle of Vogt, disc drusen, and angioid streaks) in a 38-year-old Asian woman who had tumoral calcinosis associated with hyperphosphatemia. A morphologic study of the calcified nodules on the palpebral conjunctiva disclosed deposition of hydroxyapatite crystals in an extracellular matrix (deposit) containing alcianophilic mucopolysaccharides. Excision of the eyelid nodules was not followed by recurrence.

Tezelman S, Siperstein AE, Duh Q-Y, Clark OH.  Tumoral calcinosis: controversies in the etiology and alternatives in the treatment . Arch Surg . 1993;128:737-744.Article
Inclan A.  Tumoral calcinosis . JAMA . 1943;121:490-495.Article
Lafferty FW, Reynolds ES, Pearson OH.  Tumoral calcinosis: a metabolic disease of obscure etiology . Am J Med . 1965;38:105-117.Article
Barton DL, Captain MC, Reeves RJ.  Tumoral calcinosis: report of three cases and review of the literature . AJR Am J Roentgenol . 1961;86:351-358.
Clarke E, Swischuk LE, Hayden CK.  Tumoral calcinosis, diaphysitis and hyperphosphataemia . Radiology . 1984;151:643-646.Article
Martinez S, Vogler JB, Harrelson JM, Lyles KW.  Imaging of tumoral calcinosis: new observations . Radiology . 1990;174:215-222.Article
Bruns DE. Lieb W, Conway BP, Savory J, Wills MR, Boskey AL.  Band keratopathy and calcific lid lesions in tumoral calcinosis . Arch Ophthalmol . 1988;106:725-726.Article
Bruns DE, Boskey AL, Lieb W, Conway BP, Savory J, Wills MR.  Tumoral calcinosis: seasonal biochemical studies and chemical studies of eyelid lesion . Clin Chem . 1989;35:183-185.
Morgan HG, Dryburgh FJ, Mills EA.  Tumoral calcinosis with hyperphosphataemia . In: Kuhlencordt F, Kruse HP, eds. Calcium Metabolism. Bone and Metabolic Bone Disease . New York, NY: Springer-Verlag NY Inc; 1975:356-361.
Ghadially FN. Ultrastructural Pathology of the Cell and Matrix . 3rd ed. Stoneham, Mass: Butterworths; 1988:1278-1289.
McKee PH, Liomba NG, Hutt MSR.  Tumoral calcinosis: a pathological study of 56 cases . Br J Dermatol . 1982;107:669-674.Article
Lyles KW, Burkes EJ Jr, Ellis GJ, Lucas KJ, Dolan EA, Drezner MK.  Genetic transmission of tumoral calcinosis: autosomal dominant with variable clinical expressivity . J Clin Endocrinol Metab . 1985;60:1093-1096.Article
Burke EJ Jr, Lyles KW, Dolan EA, Giammara B, Hanker J.  Dental lesions in tumoral calcinosis . J Oral Pathol Med . 1991;20:222-227.Article
Ferry AP.  Subepidermal calcified nodules of the eyelid . Am J Ophthalmol . 1990;109:85-88.
von Below H, Kuchle M.  Subepidermale Kalzinose des Oberlids [in German] . Fortschr Ophthalmol . 1991;88:165-167.
Chester RJ, de Venecia G.  Calcific eyelid margin lesions in chronic renal failure . Am J Ophthalmol . 1989;107:556-557.
Sugar HS, Kobernick S.  The white limbal girdle of Vogt . Am J Ophthalmol . 1960;50:101-107.
McPhaul JJ, Engel F.  Heterotopic calcification, hyperphosphatemia and angioid streaks . Am J Med . 1961;31:488-492.Article
Boskey AL, Vigorita VJ, Sencer O, Stuchin SA, Lane JM.  Chemical, microscopic and ultrastructural characterisation of the mineral deposits in tumoral calcinosis . Clin Orthop . 1983;178:258-269.
Berlyne GM.  Microcrystalline conjunctival calcification in renal failure . Lancet . 1968;2:366-370.Article
Dryll A, Bardin T, Lansaman J, Tran Van P, Ryckewaert A, Cywiner-Golentzer C.  Tumoral calcinosis: light and electron microscopic study with electron diffraction and x-ray microanalysis of the mineral deposit . J Submicrosc Cytol Pathol . 1984;16:577-583.
Veress B, Malik OA, El Hassan AM.  Tumoral lipocalcinosis: a clinicopathological study of 20 cases . J Pathol . 1976;119:113-118.Article