[Skip to Content]
[Skip to Content Landing]
August 1996

The Endophthalmitis Vitrectomy Study

Author Affiliations

Miami, Fla
St Louis, Mo

Arch Ophthalmol. 1996;114(8):1027-1028. doi:10.1001/archopht.1996.01100140233033

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


The recently published EVS presents the results of a randomized prospective clinical trial comparing 4 different initial treatment strategies for endophthalmitis following primary cataract surgery or secondary intraocular lens implantation.1 Although the data represent a major contribution to our knowledge of the treatment outcomes of these approaches, the conclusions in the abstract go far beyond the data presented in the article.

Using the 4 major study outcomes (visual acuity ≥20/40, ≥20/100, ≥5/200, and media clarity), the EVS demonstrated no harmful effects in the 3-port pars plana vitrectomy group compared with the needle-tap or vitrectomy-biopsy group. Furthermore, the EVS data showed the following beneficial effects in the 3-port pars plana vitrectomy group compared with the needle-tap or vitrectomy-biopsy group: (1) improved media clarity at all follow-up examinations (statistically significant at 3 months); (2) lower rates of retinal detachment; (3) lower rates of persistent positive intraocular cultures (data presented at the

Endophthalmitis Vitrectomy Study Group.  Results of the Endophthalmitis Vitrectomy Study: a randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalamitis . Arch Ophthalmol . 1995;113:1479-1496.Article
Doft BH, Donnelly K.  A single sclerotomy vitreous biopsy technique in endophthalmitis . Arch Ophthalmol . 1991;109:465.Article
El-Massry A, Meredith TA, Aguilar HE, et al. Aminoglycoside concentrations in the vitreous cavity after intravenous administration. Am J Ophthalmol. In press.
Meredith TA, Aguilar HE, Shaarawy A, Kincaid M, Dick J, Niesman R.  Vancomycin levels in the vitreous cavity after intravenous administration . Am J Ophthalmol . 1995;119:774-778.
Shaarawy A, Grand MG, Meredith TA, Ibanez H.  Persistent infection after intravitreal antimicrobial therapy . Ophthalmology . 1995;102:382-387.Article
Cottingham AJJr, Forster RK.  Vitrectomy in endophthalmitis: results of a study using vitrectomy, intraocular antibiotics, or a combination of both . Arch Ophthalmol . 1976;94:2078-2081.Article