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September 1996

Early Retinal Vessel Development and Iris Vessel Dilatation as Factors in Retinopathy of Prematurity-Reply

Author Affiliations

Milwaukee, Wis
Pittsburgh, Pa
Portland, Ore

Arch Ophthalmol. 1996;114(9):1160. doi:10.1001/archopht.1996.01100140362033

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In reply  We appreciate the interest of Drs Topilow and Ackerman in our article.1 Their clinical impression that a wider avascular zone indicated a greater probability of the ROP advancing rapidly to severe disease preceded the publication of the Multicenter Trial of Cryotherapy for ROP2 (CRYOROP) data. However, the focus of our study is different. All of the patients included in the series described by Topilow and Ackerman3-5 were treated with cryotherapy, some were treated after developing retinal detachment. Little data were presented on the patients' findings prior to the development of severe ROP,3 and no comparison was made between the size of the avascular zone in their patients and that of other premature infants who never developed threshold disease. We studied patients prior to retinal detachment or cryotherapy, and the emphasis of our report was on findings in early screening examinations that help predict an

Kivlin J, Biglan AW, Gordon RA, et al.  Early retinal vessel development and iris vessel dilatation as factors in retinopathy of prematurity . Arch Ophthalmol . 1996;114:150-154.Article
Cryotherapy for Retinopathy of Prematurity Cooperative Group.  Multicenter trial of cryotherapy for retinopathy of prematurity: three month outcome . Arch Ophthalmol . 1990;108:195-204.Article
Topilow HW, Ackerman AL, Wang FM.  The treatment of advanced retinopathy of prematurity by cryotherapy and scleral buckling surgery . Ophthalmology . 1985;92:379-387.Article
Topilow HW, Ackerman AL, Wang FM, Strome RR.  Successful treatment of advanced retinopathy of prematurity . Ophthalmic Surg . 1988;19:781-785.
Topilow HW, Ackerman AL.  Cryotherapy for stage 3+ retinopathy: visual and anatomic results . Ophthalmic Surg . 1989;20:864-871.
The Committee for the Classification of Retinopathy of Prematurity.  An international classification of retinopathy of prematurity . Arch Ophthalmol . 1984;102:1129-1134.Article