[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.147.69. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Clinicopathologic Reports, Case Reports, and Small Case Series
Octomber 2007

Macular Infarction Following Viperine Snake Bite

Arch Ophthalmol. 2007;125(10):1430-1431. doi:10.1001/archopht.125.10.1430

Macular infarction has been reported following toxic influences, for example, aminoglycoside toxicity.1 Venomous snake bites may result in neurologic or hemostatic dysfunction. Viperine (hemotoxic) snake bites may produce coagulopathy, which may result in several systemic complications. Ocular involvement is rare. Common ocular problems encountered after a snake bite are generally neurologic (ptosis, ophthalmoplegia, accommodation paralysis, and optic neuritis). Visual loss may result from direct inoculation of venom into the eye (globe necrosis, keratomalacia, and uveitis), from optic neuritis, or secondary to hemostatic abnormality (vitreous hemorrhage, cortical infarction, and central retinal artery occlusion).25

Report of a Case

A 17-year-old girl was bitten by a viperine snake. She was admitted to a local hospital in an unconscious state and administered first aid, anti–snake venom serum, and supportive care. She regained consciousness 14 hours after the snake bite and 6 hours later reported loss of vision in her left eye. She came to us 5 days later. Visual acuity was recorded as 20/20 OD and no light perception OS. Ophthalmological examination disclosed unremarkable anterior segment and normal intraocular pressures in both eyes. Relative afferent pupillary defect was observed in the left eye. Fundus examination revealed optic disc hyperemia, splinter-shaped hemorrhages at the posterior pole, and a cherry-red spot at the center of the macula (Figure 1). Fluorescein angiography demonstrated normal arm-retina (10-second) and arteriovenous transit (11-second) times. Blocked choroidal fluorescence was observed in relation to the nerve fiber layer hemorrhages. The most striking feature on fluorescein angiography was pruning of the perifoveal capillaries. The silhouette of occluded macular capillaries was observed against the choroidal flush. Late-phase angiograms showed optic disc staining (Figure 2).

Figure 1.
Fundus photograph showing a cherry-red spot at the macula and superficial retinal hemorrhages.

Fundus photograph showing a cherry-red spot at the macula and superficial retinal hemorrhages.

Figure 2.
Early (A) and late phase (B) fluorescein angiograms demonstrate pruning of the perifoveal capillaries and optic disc staining, respectively.

Early (A) and late phase (B) fluorescein angiograms demonstrate pruning of the perifoveal capillaries and optic disc staining, respectively.

Systemic examination revealed no deficit. Laboratory investigations showed mild anemia (hemoglobin level, 10.4 g/dL [to convert to grams per liter, multiply by 10.0]), leukocytosis (13 800/μL [to convert to ×109 per liter, multiply by 0.001]), and neutrophilia (74%). Results of renal function tests, abdominal ultrasonography, electrocardiography, echocardiography, and magnetic resonance imaging of the brain were normal. Dual antiplatelet therapy (aspirin, 75 mg/d, and clopidogrel, 75 mg/d), systemic antibiotics, and oral prednisone (40 mg/d tapered by 10 mg/wk) were started. Three months later, the visual acuity remained no light perception. Optic disc pallor and gross attenuation of perifoveal vessels were noted. The macula showed pigment clumping and atrophy (Figure 3).

Figure 3.
At 3-month follow-up, coarse pigment clumping and atrophy at the macula and gross attenuation of the macular arterioles are evident. Note also the optic disc pallor.

At 3-month follow-up, coarse pigment clumping and atrophy at the macula and gross attenuation of the macular arterioles are evident. Note also the optic disc pallor.

Comment

Snake venom is a complex heterogeneous composition of substances that predominantly affects the synapse (neurotoxic) or coagulation pathway (hemotoxic). Large doses can result in disseminated intravascular coagulopathy (DIC) and ischemic damage to vital organs. Toxic vasculitis has reportedly been caused by certain species of the Viperidae family.5 Hemorrhagins (complement-mediated toxic components of viperine venom) may induce severe vasospasm, endothelial damage, and increased vascular permeability. Vasospasm and/or DIC may result in vascular occlusion. Fibrin thrombi in the capillaries, perivascular hemorrhages, and necrosis, all observed in our patient, are features of DIC.

The likely cause of visual loss could be (1) ophthalmic artery occlusion with subsequent dislodge of fibrin emboli into the end arterioles at the posterior pole; or (2) retinal necrosis and macular infarction secondary to an aborted DIC process associated with toxic optic neuropathy (venom or ASV serum toxicity).

Ocular complications following a snake bite range from keratomalacia to vitreous hemorrhage,4 uveitis, optic neuritis,3 globe necrosis, and visual loss due to cortical infarction.5 We are unaware of any previous report in the literature of macular infarction following a viperine snake bite. Visual prognosis is poor despite medical treatment.

Back to top
Article Information

Correspondence: Dr Singh, Sardar Bahadur Dr Sohan Singh Eye Hospital, Katra Sher Singh, Chowk Farid, Amritsar-143006, Punjab, India (drjatinder@rediffmail.com).

Financial Disclosure: None reported.

References
1.
Campochiaro  PAConway  BP Aminoglycoside toxicity—a survey of retinal specialists: implications for ocular use. Arch Ophthalmol 1991;109 (7) 946- 950
PubMedArticle
2.
Bhalla  AJain  APBanait  S  et al.  Central retinal artery occlusion: an unusual complication of snake bite. J Venom Anim Toxins Incl Trop Dis 2004;10 (3) 311- 314Article
3.
Menon  VTandon  RSharma  TGupta  A Optic neuritis following snake bite. Indian J Ophthalmol 1997;45 (4) 236- 237
PubMed
4.
Rao  BM A case of bilateral vitreous haemorrhage following snake bite. Indian J Ophthalmol 1977;25 (2) 1- 2
PubMed
5.
Merle  HDonnio  AAyeboua  L  et al.  Occipital infarction revealed by quadranopsia following snake bite by Bothrops lanceolatusAm J Trop Med Hyg 2005;73 (3) 583- 585
PubMed
×