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Clinical Problem Solving: Pathology
Jan 2012

Pathology Quiz Case 3: Diagnosis

Arch Otolaryngol Head Neck Surg. 2012;138(1):100-101. doi:10.1001/archoto.2011.220-b

Diagnosis: Neuroblastoma with cervical metastases

Neuroblastoma is within the spectrum of peripheral neuroblastic tumors. Such neoplasms arise from the precursors of the neural crest cells that migrate to form the sympathetic nervous system, the chromaffin cells of the adrenal medulla, and the paraganglia.1,2 They account for 8% to 10% of all childhood cancers and for 15% of all childhood cancer deaths. The incidence is approximately 10 cases per million children younger than 15 years and is highest in children from birth to 4 years of age (median age, 23 months).1 Neuroblastoma is the most common malignant neoplasm diagnosed in infancy.2

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