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Clinical Note
July 2011

Rosai-Dorfman Disease Presenting in the Parotid Gland With Features of IgG4-Related Sclerosing Disease

Author Affiliations

Author Affiliations: Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Guishan Township, Taoyuan County, Taiwan.

Arch Otolaryngol Head Neck Surg. 2011;137(7):705-708. doi:10.1001/archoto.2011.52

Rosai-Dorfman disease (RDD) is an infrequently encountered disorder characterized by histiocytes exhibiting emperipolesis and varying degrees of chronic inflammatory cell infiltrates. It is generally considered an important differential diagnosis of IgG4-related sclerosing disease because of their similar histopathologic features. We report herein a case of RDD in the parotid gland with an increase in the absolute number of IgG4+ plasma cells as well as an increase in the ratio of IgG4+ to IgG+ plasma cells. We also discuss both disease entities and this overlapping phenomenon.

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