Author Affiliations: Department of Medicine (Drs Stevenson and Afghahi), Divisions of Cardiology (Dr Witteles), Otorhinolaryngology (Dr Damrose), Blood and Marrow Transplant (Dr Arai), Nephrology (Dr Lafayette), and Hematology (Drs Schrier and Liedtke) and Stanford Amyloid Center (Drs Witteles, Arai, Lafayette, Schrier, and Liedtke), Stanford University School of Medicine, Stanford, California.
Amyloidosis is a disease characterized by protein deposition in tissues and organs, most commonly the kidney, heart, liver, nervous system, and gastrointestinal tract.1 Extracellular fibrils form β-pleated sheets disrupting organ function. Over 20 different proteins have been observed in amyloidosis, but all forms are identified by Congo red stain and a green birefringence pattern under polarized light.
Stevenson R, Witteles R, Damrose E, Arai S, Lafayette RA, Schrier S, Afghahi A, Liedtke M. More Than a Frog in the ThroatA Case Series and Review of Localized Laryngeal Amyloidosis. Arch Otolaryngol Head Neck Surg. 2012;138(5):509-511. doi:10.1001/archoto.2012.423