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Clinical Problem Solving: Pathology
May 2012

Pathology Quiz Case 1: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2012;138(5):522. doi:10.1001/archoto.2012.79b

Diagnosis: Small cell carcinoma (SmCC) of the larynx

Small cell carcinoma, a type of neuroendocrine tumor, is considered to be a distinct malignant neoplasm that most commonly arises in the lung and is well known for aggressive clinical behavior. However, it has also been found in a wide range of extrapulmonary sites, including the larynx, although extrapulmonary SmCC makes up only 2.5% to 5% of all SmCCs.1 Squamous cell carcinoma is the most common laryngeal cancer (95%), followed by the neuroendocrine neoplasms.2,3

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