Author Affiliations: Departments of Ear, Nose, and Throat (Drs Virk, Stamatoglou, Kwame, and Sandhu) and Histopathology (Dr Sandison), Charing Cross Hospital, and Department of Renal Medicine, Hammersmith Hospital (Dr Salama), Imperial College Healthcare National Health Service Trust, London, England.
Immunoglobulin G (IgG) molecules are a family of glycoproteins involved predominantly in the anamnestic or secondary immune response and comprise 4 subclasses (IgG1-4) that vary in their capacity to trigger effector functions and their serum prevalence, with IgG4 being the least abundant.1 During autoimmune disease processes, the normally protective antimicrobial function of these molecules is targeted to healthy tissues, often with deleterious consequences.
Virk JS, Stamatoglou C, Kwame I, Salama A, Sandison A, Sandhu G. IgG4-Sclerosing Pseudotumor of the TracheaA Case Report and Review of the Literature. Arch Otolaryngol Head Neck Surg. 2012;138(9):864-866. doi:10.1001/archoto.2012.1821