The use of serum biomarkers for cancer screening, such as prostate-specific antigen, can provide a valuable and easily recognizable tool for an initial evaluation for the presence of head and neck squamous cell cancer (HNSCC). Kaskas and colleagues evaluated serum samples from 50 patients with advanced HNSCC and compared them against those of 20 controls for serum cytokine and chemokine concentrations. They found significantly decreased levels of interferon-γ, interleukin-13, and macrophage inflammatory protein 1β and elevated inducible protein 10 in the patients with HNSCC, laying the groundwork for a future study.
Highlights. JAMA Otolaryngol Head Neck Surg. 2014;140(1):3. doi:10.1001/jamaoto.2013.4270