As the incidence of mouth cancer in nonsmokers has been increasing, Perry and associates explored the possibility of etiologies other than human papillomavirus. They performed a retrospective analysis of 881 patients with oral cavity and oropharyngeal cancer from 2001 to 2011. Oral cavity cancers were on the lateral tongue, a site of potential trauma, in a majority of the nonsmokers, and lingual/floor of mouth cancers were in an older population, potentially in sites of denture trauma. The authors noted that recognizing and treating sites of dental inflammation might decrease the risk of these cancers in the latter group.
Highlights. JAMA Otolaryngol Head Neck Surg. 2015;141(1):3. doi:10.1001/jamaoto.2014.2132