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Residents Page: Pathology
June 1998

Pathologic Quiz Case 2

Author Affiliations
 

FREDERIC B.ASKINMDWILLIAM H.WESTRAMD

Arch Otolaryngol Head Neck Surg. 1998;124(6):717. doi:10.1001/archotol.124.6.714

Leiomyosarcoma is the malignant counterpart of leiomyoma, both of which are neoplastic derivatives of smooth muscle. As such, these neoplasms may theoretically arise anywhere in the human body, given the existence of smooth muscle in the walls of blood vessels. While leiomyosarcomas account for approximately 7%1 of all soft tissue sarcomas, and are not infrequent in the gastrointestinal tract and uterus, they are uncommon in the head and neck. Nine (1.5%) of 602 soft tissue otolaryngologic tumors registered with the Armed Forces Institute of Pathology between 1970 and 1988 were leiomyosarcomas.2 Leiomyosarcoma was found to represent 2.3% of nonepithelial sinonasal and nasopharyngeal tumors in one study,3 and a recent review noted 40 cases of nasal leiomyosarcoma reported to date.4 There is no apparent sex, age, or ethnic predilection, and there are no substantiated risk factors; however, cyclophosphamide exposure has been implicated.5

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