Scopulariopsis acremonium is a species of saprophytic fungus not previously reported to cause invasive disease in humans, although invasive infections from other species of Scopulariopsis have been reported and are reviewed. Deep infection with this fungus is associated with a high mortality rate. Invasive fungal sinusitis, in general, is a potentially fatal disease that typically affects immunocompromised patients, such as those receiving intensive chemotherapy or undergoing bone marrow transplantation. We report a case of invasive fungal sinusitis caused by Scopulariopsis acremonium in a patient with leukemia, who was successfully treated with amphotericin B, itraconazole, endoscopic sinus surgery, and granulocyte colony-stimulating factor.
Ellison MD, Hung RT, Harris K, Campbell BH. Report of the First Case of Invasive Fungal Sinusitis Caused by Scopulariopsis acremoniumReview of Scopulariopsis Infections. Arch Otolaryngol Head Neck Surg. 1998;124(9):1014-1016. doi:10.1001/archotol.124.9.1014